PMID- 10503948
OWN - NLM
STAT- MEDLINE
DCOM- 19991007
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 65
IP  - 12
DP  - 1999
TI  - Interleukin-6 and transforming growth factor-beta regulate the expression of 
      monocyte chemoattractant protein-1 and colony-stimulating factors in human 
      thyroid follicular cells.
PG  - PL129-35
AB  - Monocytes and T-lymphocytes, both of which play a pivotal role in 
      immune/inflammatory responses, can be attracted from the circulation into tissues 
      by monocyte chemoattractant protein-1 (MCP-1), and monocytes can be further 
      activated by colony-stimulating factors (CSFs), granulocyte/macrophage CSF 
      (GM-CSF) or macrophage CSF (M-CSF). We examined whether either interleukin-6 
      (IL-6) or transforming growth factor-beta (TGF-beta), both of which are produced 
      by thyroid follicular cells (TFC), can regulate the production of MCP-1 or CSF(s) 
      in human TFC. IL-6, being effective only in the presence of soluble IL-6 receptor 
      (sIL-6R), stimulated the expression of both MCP-1 and M-CSF, but was inhibitory 
      on GM-CSF expression. On the other hand, TGF-beta stimulated the expression of 
      both MCP-I and GM-CSF, but suppressed M-CSF expression. These results suggest a 
      possible role of IL-6 or TGF-beta on the initiation and/or modulation of thyroid 
      immune/inflammatory responses via MCP-1 production and differential production of 
      GM-CSF or M-CSF by TFC.
FAU - Matsumura, M
AU  - Matsumura M
AD  - Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, 
      Mibu, Tochigi, Japan. matsumura@dokkyomed.ac.jp
FAU - Banba, N
AU  - Banba N
FAU - Motohashi, S
AU  - Motohashi S
FAU - Hattori, Y
AU  - Hattori Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Transforming Growth Factor beta)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
RN  - 9002-71-5 (Thyrotropin)
RN  - EC 1.11.1.8 (Iodide Peroxidase)
SB  - IM
MH  - Cells, Cultured
MH  - Chemokine CCL2/*biosynthesis
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/*biosynthesis
MH  - Humans
MH  - Interleukin-6/*pharmacology
MH  - Iodide Peroxidase/genetics
MH  - Macrophage Colony-Stimulating Factor/*biosynthesis
MH  - Thyroid Gland/cytology/drug effects/*metabolism
MH  - Thyrotropin/pharmacology
MH  - Transforming Growth Factor beta/*pharmacology
EDAT- 1999/09/30 00:00
MHDA- 1999/09/30 00:01
CRDT- 1999/09/30 00:00
PHST- 1999/09/30 00:00 [pubmed]
PHST- 1999/09/30 00:01 [medline]
PHST- 1999/09/30 00:00 [entrez]
AID - S0024320599003689 [pii]
AID - 10.1016/s0024-3205(99)00368-9 [doi]
PST - ppublish
SO  - Life Sci. 1999;65(12):PL129-35. doi: 10.1016/s0024-3205(99)00368-9.