PMID- 10504198
OWN - NLM
STAT- MEDLINE
DCOM- 19991110
LR  - 20071114
IS  - 0022-3034 (Print)
IS  - 0022-3034 (Linking)
VI  - 41
IP  - 1
DP  - 1999 Oct
TI  - Trophic regulation of synaptic plasticity.
PG  - 108-18
AB  - Trophins are now known to acutely regulate synaptic plasticity, in addition to 
      exerting long-recognized actions on neuronal survival and development. To begin 
      elucidating underlying mechanisms, cultured dissociated hippocampal neurons were 
      examined by whole-cell patch-clamp recording. BDNF (brain derived neurotrophic 
      factor) specifically and selectively increased the integrated synaptic current 
      twofold within five minutes. The effect was mediated postsynaptically by the trkB 
      receptor and intracellular phosphorylation-dependent mechanisms. Iontophoresis 
      combined with patch-clamp recording indicated that BDNF increased activity of 
      NMDA (N-methyl-D-aspartate) receptors. Single channel-channel recording indicated 
      that BDNF increased channel open probability by increasing opening frequency. In 
      parallel, the trophin specifically increased phosphorylation of NR1 and NR2B 
      subunits of NMDA receptors in the postsynaptic density, providing potential 
      mechanisms eliciting receptor activation. A model is proposed in which 
      activity-driven experience activates specific BDNF gene promoters, leading to 
      enhanced transcription, elevated trophin levels, postsynaptic NMDA receptor 
      activation and increased synaptic transmission. These sequential mechanisms may 
      contribute to enhanced long-term potentiation, a correlate of learning and 
      memory.
CI  - Copyright 1999 John Wiley & Sons, Inc.
FAU - Black, I B
AU  - Black IB
AD  - Department of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson Medical 
      School, 675 Hoes Lane, Piscataway, New Jersey 08854-5635, USA.
LA  - eng
GR  - HD23315/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Neurobiol
JT  - Journal of neurobiology
JID - 0213640
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Brain Chemistry/*physiology
MH  - Nerve Growth Factors/*physiology
MH  - Neuronal Plasticity/*physiology
RF  - 36
EDAT- 1999/09/30 00:00
MHDA- 1999/09/30 00:01
CRDT- 1999/09/30 00:00
PHST- 1999/09/30 00:00 [pubmed]
PHST- 1999/09/30 00:01 [medline]
PHST- 1999/09/30 00:00 [entrez]
AID - 10.1002/(SICI)1097-4695(199910)41:1<108::AID-NEU14>3.0.CO;2-U [pii]
PST - ppublish
SO  - J Neurobiol. 1999 Oct;41(1):108-18.