PMID- 10504466
OWN - NLM
STAT- MEDLINE
DCOM- 19991202
LR  - 20051116
IS  - 0085-2538 (Print)
IS  - 0085-2538 (Linking)
VI  - 56
IP  - 4
DP  - 1999 Oct
TI  - Glomerular ultrafiltration and apical tubular action of IGF-I, TGF-beta, and HGF 
      in nephrotic syndrome.
PG  - 1247-51
AB  - In nephrotic glomerulopathies, there is ultrafiltration of high molecular weight 
      forms of insulin-like growth factor-I (IGF-I), hepatocyte growth factor (HGF), 
      and transforming growth factor-beta (TGF-beta), which are bioactive in tubular 
      fluid and act through apical tubular receptors. Experimental evidence indicates 
      that ultrafiltered IGF-I, HGF, and TGF-beta may contribute to increased tubular 
      phosphate and sodium absorption, synthesis of extracellular matrix proteins, and 
      secretion of chemokines such as monocyte chemoattractant protein-1 (MCP-1). 
      Through these mechanisms, glomerular proteinuria may contribute to 
      tubulointerstitial pathobiology in nephrotic syndrome.
FAU - Wang, S N
AU  - Wang SN
AD  - Division of Nephrology and Hypertension, Harbor-UCLA Medical Center and UCLA, 
      Torrance, California 90509, USA.
FAU - Lapage, J
AU  - Lapage J
FAU - Hirschberg, R
AU  - Hirschberg R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (Transforming Growth Factor beta)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Hepatocyte Growth Factor/*metabolism
MH  - Humans
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Kidney Glomerulus/metabolism/*physiopathology
MH  - Kidney Tubules/*metabolism
MH  - Nephrotic Syndrome/metabolism/*physiopathology
MH  - Transforming Growth Factor beta/*metabolism
MH  - Ultrafiltration
RF  - 18
EDAT- 1999/10/03 00:00
MHDA- 1999/10/03 00:01
CRDT- 1999/10/03 00:00
PHST- 1999/10/03 00:00 [pubmed]
PHST- 1999/10/03 00:01 [medline]
PHST- 1999/10/03 00:00 [entrez]
AID - S0085-2538(15)46423-3 [pii]
AID - 10.1046/j.1523-1755.1999.00698.x [doi]
PST - ppublish
SO  - Kidney Int. 1999 Oct;56(4):1247-51. doi: 10.1046/j.1523-1755.1999.00698.x.