PMID- 10505560
OWN - NLM
STAT- MEDLINE
DCOM- 19991028
LR  - 20200109
IS  - 0896-8608 (Print)
IS  - 0896-8608 (Linking)
VI  - 18
IP  - 4
DP  - 1998 Jul-Aug
TI  - Serum C-reactive protein: a predictor of mortality in continuous ambulatory 
      peritoneal dialysis patients.
PG  - 387-94
AB  - OBJECTIVE: To evaluate the predictive value of a single baseline serum C-reactive 
      protein (sCRP) as a marker of mortality in continuous ambulatory peritoneal 
      dialysis (CAPD) patients. DESIGN: A review of prospectively collected data in a 
      2-year follow-up study. SETTING: Tertiary medical center. PATIENTS: The study 
      included 106 patients who were stable and had been on CAPD for a minimum of 3 
      months. MAIN OUTCOME MEASURES: Patient survival rate was the main outcome measure 
      of this study. Other outcome measures were technique survival rate, peritonitis 
      rate, and hospitalized days. Covariables used in the survival analysis were age, 
      sex, the presence of cardiovascular disease or diabetes mellitus, sCRP, serum 
      albumin, hematocrit, cholesterol, HDL-cholesterol, malnutrition by subjective 
      global assessment (SGA), weekly Kt/V urea, and weekly standardized creatinine 
      clearance (SCCr). RESULTS: The 2-year patient survival rate was significantly 
      lower in the increased sCRP group than in the normal sCRP group (66.7% vs 94.1%, 
      p = 0.001), although there was no significant difference in technique failure, 
      peritonitis rate, and hospitalized days between the two groups. By Cox 
      proportional hazards analysis, independent predictors of mortality were: 
      cardiovascular disease (relative risk, RR = 8.96, p < 0.005); increased sCRP 
      level (RR = 1.19, p < 0.05); and high hematocrit (RR = 1.18, p < 0.05). 
      CONCLUSION: Serum CRP at enrollment is an independent predictor of 2-year patient 
      survival in CAPD patients.
FAU - Noh, H
AU  - Noh H
AD  - Department of Internal Medicine, Institute of Kidney Disease, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Lee, S W
AU  - Lee SW
FAU - Kang, S W
AU  - Kang SW
FAU - Shin, S K
AU  - Shin SK
FAU - Choi, K H
AU  - Choi KH
FAU - Lee, H Y
AU  - Lee HY
FAU - Han, D S
AU  - Han DS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perit Dial Int
JT  - Peritoneal dialysis international : journal of the International Society for 
      Peritoneal Dialysis
JID - 8904033
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Serum Albumin)
RN  - 8W8T17847W (Urea)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Age Factors
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*analysis
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Creatinine/blood
MH  - Diabetes Complications
MH  - Female
MH  - Follow-Up Studies
MH  - Forecasting
MH  - Heart Diseases/complications
MH  - Hematocrit
MH  - Hospitalization
MH  - Humans
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Nutrition Disorders/complications
MH  - *Peritoneal Dialysis, Continuous Ambulatory/adverse effects
MH  - Peritonitis/etiology
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Serum Albumin/analysis
MH  - Sex Factors
MH  - Survival Analysis
MH  - Survival Rate
MH  - Urea/blood
EDAT- 1999/10/03 00:00
MHDA- 1999/10/03 00:01
CRDT- 1999/10/03 00:00
PHST- 1999/10/03 00:00 [pubmed]
PHST- 1999/10/03 00:01 [medline]
PHST- 1999/10/03 00:00 [entrez]
PST - ppublish
SO  - Perit Dial Int. 1998 Jul-Aug;18(4):387-94.