PMID- 10505748
OWN - NLM
STAT- MEDLINE
DCOM- 19991118
LR  - 20161124
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 19
IP  - 9
DP  - 1999 Sep
TI  - Chemokines are upregulated during orthodontic tooth movement.
PG  - 1047-52
AB  - In the early stage of orthodontic tooth movement, an acute inflammatory response 
      characterized by the migration of leukocytes occurs. This response suggests the 
      presence of specific chemotactic signals that may play a role in the mechanism of 
      bone remodeling, in particular in resorption. The aim of the present study was to 
      explore the induction of potential chemokines at the resorption side during 
      orthodontic tooth movement. Monocyte chemoattractant protein-1 (MCP-1), regulated 
      on activation normal T cell expressed and secreted (RANTES), and macrophage 
      inflammatory protein-2 (MIP-2) were examined by in situ hybridization using 
      radioactive synthetic oligoneucleotide probes. Mesial movement of the upper first 
      molars was performed with a fixed appliance for 3, 7, and 10 days. The results 
      demonstrated that MCP-1, RANTES, and MIP-2 were highly expressed during 
      orthodontic movement. On day 3, MCP-1 showed maximum induction in the pressure 
      zone, followed in intensity by RANTES and MIP-2, although not in the 
      contralateral control side. The induction of these chemokines had declined on day 
      7 and reached low levels on day 10. Our data suggest that chemokines are induced 
      early in the application of force, and such induction may contribute to the early 
      inflammatory response that may be responsible in part for the ensuing bone 
      remodeling.
FAU - Alhashimi, N
AU  - Alhashimi N
AD  - Division of Infectious Diseases, Karolinska Institutet, Huddinge University 
      Hospital, Sweden.
FAU - Frithiof, L
AU  - Frithiof L
FAU - Brudvik, P
AU  - Brudvik P
FAU - Bakhiet, M
AU  - Bakhiet M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Chemokines)
SB  - IM
MH  - Animals
MH  - Chemokines/*metabolism
MH  - In Situ Hybridization
MH  - Inflammation/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - *Tooth Movement Techniques
MH  - Up-Regulation
EDAT- 1999/10/03 00:00
MHDA- 1999/10/03 00:01
CRDT- 1999/10/03 00:00
PHST- 1999/10/03 00:00 [pubmed]
PHST- 1999/10/03 00:01 [medline]
PHST- 1999/10/03 00:00 [entrez]
AID - 10.1089/107999099313271 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 1999 Sep;19(9):1047-52. doi: 10.1089/107999099313271.