PMID- 10508318
OWN - NLM
STAT- MEDLINE
DCOM- 19991115
LR  - 20190915
IS  - 1053-1807 (Print)
IS  - 1053-1807 (Linking)
VI  - 10
IP  - 4
DP  - 1999 Oct
TI  - Cerebral (1)H MRS alterations in recreational 3, 4-methylenedioxymethamphetamine 
      (MDMA, "ecstasy") users.
PG  - 521-6
AB  - 3,4-methylenedioxymethamphetamine (MDMA) is an illicit drug that has been 
      associated with serotonergic axonal degeneration in animals. This study evaluates 
      neurochemical abnormalities in recreational MDMA users. Twenty-two MDMA users and 
      37 normal subjects were evaluated with magnetic resonance imaging (MRI) and 
      proton magnetic resonance spectroscopy ((1)H MRS) in the mid-frontal, 
      mid-occipital, and parietal brain regions. (1)H MRS showed normal N-acetyl (NA) 
      compounds in all brain regions. The myo-inositol (MI) concentration (+16.3%, P = 
      0.04) and the MI to creatine (CR) ratio (+14.1%, P = 0. 01) were increased in the 
      parietal white matter of MDMA users. The cumulative lifetime MDMA dose showed 
      significant effects on [MI] in the parietal white matter and the occipital 
      cortex. The normal NA concentration suggests a lack of significant neuronal 
      injury in recreational MDMA users. However, the usage-related increase in MI 
      suggests that exposure to MDMA, even at recreational doses, may cause increased 
      glial content. J. Magn. Reson. Imaging 1999;10:521-526.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Chang, L
AU  - Chang L
AD  - Department of Neurology, UCLA School of Medicine, Harbor-UCLA Medical Center, 
      Torrance, California 90502, USA. Linda_Chang@humc.edu
FAU - Ernst, T
AU  - Ernst T
FAU - Grob, C S
AU  - Grob CS
FAU - Poland, R E
AU  - Poland RE
LA  - eng
GR  - DA00280/DA/NIDA NIH HHS/United States
GR  - MH00534/MH/NIMH NIH HHS/United States
GR  - MO1 RR00425/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Hallucinogens)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 4L6452S749 (Inositol)
RN  - 997-55-7 (N-acetylaspartate)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - MU72812GK0 (Creatine)
RN  - N91BDP6H0X (Choline)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aspartic Acid/analogs & derivatives/analysis
MH  - Brain/*drug effects/pathology
MH  - *Brain Chemistry
MH  - Choline/analysis
MH  - Creatine/analysis
MH  - Female
MH  - Hallucinogens/*adverse effects
MH  - Humans
MH  - Inositol/analysis
MH  - Magnetic Resonance Imaging
MH  - *Magnetic Resonance Spectroscopy
MH  - Male
MH  - Middle Aged
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - Substance-Related Disorders/*metabolism/pathology
EDAT- 1999/10/03 00:00
MHDA- 1999/10/03 00:01
CRDT- 1999/10/03 00:00
PHST- 1999/10/03 00:00 [pubmed]
PHST- 1999/10/03 00:01 [medline]
PHST- 1999/10/03 00:00 [entrez]
AID - 10.1002/(SICI)1522-2586(199910)10:4<521::AID-JMRI4>3.0.CO;2-9 [pii]
AID - 10.1002/(sici)1522-2586(199910)10:4<521::aid-jmri4>3.0.co;2-9 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 1999 Oct;10(4):521-6. doi: 
      10.1002/(sici)1522-2586(199910)10:4<521::aid-jmri4>3.0.co;2-9.