PMID- 10509502
OWN - NLM
STAT- MEDLINE
DCOM- 19991026
LR  - 20190611
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 354
IP  - 9184
DP  - 1999 Sep 25
TI  - Haemophilus influenzae type b meningitis in The Gambia after introduction of a 
      conjugate vaccine.
PG  - 1091-2
AB  - After the introduction of a Haemophilus Influenzae type b (Hib) conjugate vaccine 
      into The Gambia, the annual incidence of Hib meningitis has fallen from more than 
      200 per 100,000 before vaccination to 21 per 100,000 during the past 12 months.
FAU - Adegbola, R A
AU  - Adegbola RA
FAU - Usen, S O
AU  - Usen SO
FAU - Weber, M
AU  - Weber M
FAU - Lloyd-Evans, N
AU  - Lloyd-Evans N
FAU - Jobe, K
AU  - Jobe K
FAU - Mulholland, K
AU  - Mulholland K
FAU - McAdam, K P
AU  - McAdam KP
FAU - Greenwood, B M
AU  - Greenwood BM
FAU - Milligan, P J
AU  - Milligan PJ
LA  - eng
PT  - Letter
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Haemophilus Vaccines)
RN  - 0 (Vaccines, Conjugate)
SB  - IM
MH  - Gambia/epidemiology
MH  - *Haemophilus Vaccines
MH  - *Haemophilus influenzae type b
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Meningitis, Haemophilus/*epidemiology/prevention & control
MH  - Vaccines, Conjugate
OID - PIP: 145212
OID - POP: 00288589
OAB - This paper reports on the impact of Haemophilus influenzae type b (Hib) conjugate 
      vaccine on the incidence of Hib meningitis in Gambia. The incidence of Hib 
      meningitis among infants younger than 12 months of age in Gambia is greater, and 
      the children affected are younger, compared to children in more developed 
      countries. Between March 1993 and December 1995, children who were administered 
      diphtheria-tetanus-pertussis (DTP) vaccination were randomly assigned a course of 
      Hib conjugate vaccine mixed with DTP or DTP only. In Gambia, DTP vaccinations are 
      recommended at 2, 3, and 4 months of age. The coverage of these vaccinations has 
      been over 85% since 1990. Hib disease has not disappeared from Gambia in the last 
      2 years since the national immunization program was introduced. However, the 
      incidence rate has declined rapidly, and a longer period of vaccination may be 
      needed to achieve a sufficient herd effect to protect unimmunized children.
OABL- eng
OTO - PIP
OT  - Africa
OT  - Africa South Of The Sahara
OT  - Age Factors
OT  - Biology
OT  - Central Nervous System
OT  - *Central Nervous System Effects
OT  - *Child Health
OT  - Delivery Of Health Care
OT  - Demographic Factors
OT  - Developing Countries
OT  - Diseases
OT  - English Speaking Africa
OT  - Gambia
OT  - Health
OT  - Health Services
OT  - Immunization
OT  - *Infant
OT  - Physiology
OT  - Population
OT  - Population Characteristics
OT  - Primary Health Care
OT  - *Research Report
OT  - *Vaccination
OT  - *Vaccines
OT  - *Viral Diseases--prevention and control
OT  - Western Africa
OT  - Youth
GN  - PIP: TJ: LANCET.
EDAT- 1999/10/06 00:00
MHDA- 1999/10/06 00:01
CRDT- 1999/10/06 00:00
PHST- 1999/10/06 00:00 [pubmed]
PHST- 1999/10/06 00:01 [medline]
PHST- 1999/10/06 00:00 [entrez]
AID - S014067369903010X [pii]
AID - 10.1016/s0140-6736(99)03010-x [doi]
PST - ppublish
SO  - Lancet. 1999 Sep 25;354(9184):1091-2. doi: 10.1016/s0140-6736(99)03010-x.