PMID- 10509920
OWN - NLM
STAT- MEDLINE
DCOM- 19991104
LR  - 20190819
IS  - 0960-894X (Print)
IS  - 0960-894X (Linking)
VI  - 9
IP  - 18
DP  - 1999 Sep 20
TI  - Combinatorial search of substituted beta-cyclodextrins for phosphatase-like 
      activity.
PG  - 2705-10
AB  - Thirteen per-6-akylamino-6-deoxy-beta-cyclodextrin libraries (beta-CD libraries) 
      were generated by a solution-phase combinatorial synthesis starting from 
      per-6-iodo-6-deoxy-beta-CD and different combinations of eleven individual amine 
      nucleophiles. Certain libraries showed the ability to hydrolyzep-nitrophenyl 
      phosphate in the presence of Zn2+.
FAU - Yu, J
AU  - Yu J
AD  - Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The 
      University of Illinois at Chicago, 60612, USA.
FAU - Zhao, Y
AU  - Zhao Y
FAU - Holterman, M J
AU  - Holterman MJ
FAU - Venton, D L
AU  - Venton DL
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Bioorg Med Chem Lett
JT  - Bioorganic & medicinal chemistry letters
JID - 9107377
RN  - 0 (Cyclodextrins)
RN  - 0 (beta-Cyclodextrins)
RN  - EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
RN  - JV039JZZ3A (betadex)
SB  - IM
MH  - Combinatorial Chemistry Techniques
MH  - Cyclodextrins/*chemical synthesis/chemistry/metabolism
MH  - Kinetics
MH  - Mass Spectrometry
MH  - Molecular Structure
MH  - Phosphoric Monoester Hydrolases/*metabolism
MH  - *beta-Cyclodextrins
EDAT- 1999/10/06 00:00
MHDA- 1999/10/06 00:01
CRDT- 1999/10/06 00:00
PHST- 1999/10/06 00:00 [pubmed]
PHST- 1999/10/06 00:01 [medline]
PHST- 1999/10/06 00:00 [entrez]
AID - S0960894X99004680 [pii]
AID - 10.1016/s0960-894x(99)00468-0 [doi]
PST - ppublish
SO  - Bioorg Med Chem Lett. 1999 Sep 20;9(18):2705-10. doi: 
      10.1016/s0960-894x(99)00468-0.