PMID- 10511451
OWN - NLM
STAT- MEDLINE
DCOM- 19991102
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 10
IP  - 13
DP  - 1999 Sep 9
TI  - Expression of mRNAs encoding full-length and truncated TrkB receptors in rat 
      dorsal root ganglia and spinal cord following peripheral inflammation.
PG  - 2847-51
AB  - Peripheral inflammation induces an increased brain-derived neurotrophic factor 
      (BDNF) synthesis in the dorsal root ganglion (DRG) and an elevated anterograde 
      transport of BDNF to axon terminals in the spinal dorsal horn. To characterize 
      whether expression of trkB is modulated in response to BDNF elevation in these 
      areas, we evaluated changes in expression of full-length and truncated trkB 
      (trkB.FL and trkB.T) mRNAs after injection of complete Freund's adjuvant into the 
      hind paw of the rat. Reverse transcription-polymerase chain reaction analysis 
      revealed that BDNF and trkB.T mRNAs levels in the DRG increased, while no change 
      of expression of trkB.FL mRNA was observed. There was no detectable change in 
      both trkB.FL and trkB.T mRNAs levels in the spinal cord. Considering that trkB.T 
      mRNA is expressed mainly in the perineuronal satellite cells, these results 
      suggest a possible paracrine role of BDNF within the DRG in addition to an 
      important role related with nociception following peripheral inflammation.
FAU - Lee, S L
AU  - Lee SL
AD  - Department of Anatomy, School of Medicine, Kyungpook National University, Dongin 
      Dong, Taegu, Korea.
FAU - Kim, J K
AU  - Kim JK
FAU - Kim, D S
AU  - Kim DS
FAU - Cho, H J
AU  - Cho HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Peptide Fragments)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Electrophoresis
MH  - Ganglia, Spinal/*metabolism
MH  - *Hindlimb
MH  - Inflammation/*metabolism
MH  - Male
MH  - Peptide Fragments/genetics
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Spinal Cord/*metabolism
EDAT- 1999/10/08 00:00
MHDA- 1999/10/08 00:01
CRDT- 1999/10/08 00:00
PHST- 1999/10/08 00:00 [pubmed]
PHST- 1999/10/08 00:01 [medline]
PHST- 1999/10/08 00:00 [entrez]
AID - 10.1097/00001756-199909090-00027 [doi]
PST - ppublish
SO  - Neuroreport. 1999 Sep 9;10(13):2847-51. doi: 10.1097/00001756-199909090-00027.