PMID- 10512379
OWN - NLM
STAT- MEDLINE
DCOM- 19991019
LR  - 20190515
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 48
IP  - 10
DP  - 1999 Oct
TI  - Tumor necrosis factor-alpha-238 and -308 polymorphisms do not associated with 
      traits related to obesity and insulin resistance.
PG  - 2096-8
AB  - Tumor necrosis factor-alpha (TNF-alpha) is expressed primarily in adipocytes, and 
      elevated levels of this cytokine have been linked to obesity and insulin 
      resistance. The purpose of this investigation was to test whether the 
      TNF-alpha-308 polymorphism (previously linked to insulin resistance and increased 
      leptin levels) and the TNF-alpha-238 polymorphism (linked to decreased insulin 
      resistance) were associated with insulin resistance or obesity-related traits in 
      424 subjects self-referred to the Johns Hopkins Weight Management Center (JHWMC). 
      There were no differences in allele frequencies of either polymorphism by obesity 
      category in the JHWMC and a lean control group. Despite previous smaller studies 
      that have linked insulin resistance and the 308 allele, we found no such 
      relationship in the JHWMC population. Instead, homozygotes for this allele had a 
      significantly lower BMI than their counterparts without the polymorphism. In 
      addition, we found no relationship between the 238 polymorphism and BMI, fasting 
      glucose, or log of fasting insulin.
FAU - Walston, J
AU  - Walston J
AD  - Division of Geriatric Medicine and Gerontology, Johns Hopkins Medical 
      Institutions, Baltimore, Maryland, USA. jwalston@welchlink.welch.jhu.edu
FAU - Seibert, M
AU  - Seibert M
FAU - Yen, C J
AU  - Yen CJ
FAU - Cheskin, L J
AU  - Cheskin LJ
FAU - Andersen, R E
AU  - Andersen RE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Body Mass Index
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Insulin Resistance/*genetics
MH  - Male
MH  - Middle Aged
MH  - Obesity/*genetics
MH  - *Polymorphism, Genetic
MH  - *Quantitative Trait, Heritable
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 1999/10/08 00:00
MHDA- 1999/10/08 00:01
CRDT- 1999/10/08 00:00
PHST- 1999/10/08 00:00 [pubmed]
PHST- 1999/10/08 00:01 [medline]
PHST- 1999/10/08 00:00 [entrez]
AID - 10.2337/diabetes.48.10.2096 [doi]
PST - ppublish
SO  - Diabetes. 1999 Oct;48(10):2096-8. doi: 10.2337/diabetes.48.10.2096.