PMID- 10512925
OWN - NLM
STAT- MEDLINE
DCOM- 19991110
LR  - 20190727
IS  - 0039-2499 (Print)
IS  - 0039-2499 (Linking)
VI  - 30
IP  - 10
DP  - 1999 Oct
TI  - The A677V methylenetetrahydrofolate reductase gene polymorphism and carotid 
      atherosclerosis.
PG  - 2180-2
AB  - BACKGROUND AND PURPOSE: The alanine/valine (A/V) polymorphism at codon 677 of the 
      5,10 methylenetetrahydrofolate reductase (MTHFR) gene correlates with elevated 
      levels of plasma homocysteine and with an increased risk of atherosclerotic 
      cardiovascular disease. Our study was designed to assess the frequency of the A 
      and V alleles in patients with asymptomatic severe carotid artery stenosis (CAS) 
      assessed by extracranial duplex examination in comparison with age- and 
      sex-matched subjects without carotid atherosclerosis. METHODS: Consecutive 
      patients (n=48; 28 men, mean+/-SD age 67.1+/-11. 4 years) with asymptomatic 
      severe (>75%) CAS were compared with subjects without CAS (n=26; 15 men, aged 
      61.2+/-11.5). The MTHFR genotype was analyzed by polymerase chain reaction 
      followed by HinfI digestion. The chi(2) analysis and t test were used to compare 
      the groups. RESULTS: The frequency of V alleles was significantly higher in the 
      CAS group (0.47) compared with control subjects (0.27, chi(2) test; OR 2.4 [95% 
      CI 1.1 to 5.3]; P<0.02). CONCLUSIONS: Our results indicate that the MTHFR A677V 
      allele is significantly associated with severe CAS.
FAU - Bova, I
AU  - Bova I
AD  - Stroke Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler 
      Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Chapman, J
AU  - Chapman J
FAU - Sylantiev, C
AU  - Sylantiev C
FAU - Korczyn, A D
AU  - Korczyn AD
FAU - Bornstein, N M
AU  - Bornstein NM
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - EC 1.5.- (Oxidoreductases Acting on CH-NH Group Donors)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
RN  - HG18B9YRS7 (Valine)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
CIN - Stroke. 2000 Apr;31(4):990-1. PMID: 10754009
CIN - Stroke. 2000 Apr;31(4):990. PMID: 10754661
MH  - Aged
MH  - *Alanine
MH  - Arteriosclerosis/*genetics
MH  - Carotid Artery Diseases/*genetics
MH  - Female
MH  - Genotype
MH  - Homocysteine/blood
MH  - Humans
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)
MH  - Oxidoreductases Acting on CH-NH Group Donors/*genetics
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - *Valine
EDAT- 1999/10/08 09:00
MHDA- 2000/05/29 09:00
CRDT- 1999/10/08 09:00
PHST- 1999/10/08 09:00 [pubmed]
PHST- 2000/05/29 09:00 [medline]
PHST- 1999/10/08 09:00 [entrez]
AID - 10.1161/01.str.30.10.2180 [doi]
PST - ppublish
SO  - Stroke. 1999 Oct;30(10):2180-2. doi: 10.1161/01.str.30.10.2180.