PMID- 10513800
OWN - NLM
STAT- MEDLINE
DCOM- 19991027
LR  - 20151119
IS  - 0004-3591 (Print)
IS  - 0004-3591 (Linking)
VI  - 42
IP  - 9
DP  - 1999 Sep
TI  - Serum levels of hyaluronan, antigenic keratan sulfate, matrix metalloproteinase 
      3, and tissue inhibitor of metalloproteinases 1 change predictably in rheumatoid 
      arthritis patients who have begun activity after a night of bed rest.
PG  - 1861-9
AB  - OBJECTIVE: To evaluate whether and how moderate physical activity following a 
      night of rest influences serum levels of matrix metalloproteinase 3 (MMP-3), 
      tissue inhibitor of metalloproteinases 1 (TIMP-1), antigenic keratan sulfate (Ag 
      KS), and hyaluronan (HA) in 10 normal subjects and 38 patients with rheumatoid 
      arthritis (RA). METHODS: Blood was obtained from 20 RA patients before they arose 
      from a night's sleep, and again 1 and 4 hours after they had begun to perform 
      moderate physical activity. Another 18 RA patients remained in bed and blood was 
      sampled at the same time periods. Serum levels of MMP-3, TIMP-1, Ag KS, and HA 
      were measured by enzyme-linked immunosorbent assay. Clinical activity was 
      evaluated by the Lansbury index. RESULTS: Both in normal subjects and in RA 
      patients who did not remain in bed throughout the period of blood sampling, 
      levels of HA, Ag KS, and MMP-3 increased significantly during the first hour 
      after the subjects arose: the increase in HA and Ag KS correlated with the 
      Lansbury index in the RA group. Three hours later, levels of Ag KS had dropped to 
      baseline values in both groups of subjects. Levels of HA remained significantly 
      and moderately elevated in the RA group but not in the control group, while 
      levels of MMP-3 did not drop significantly in either group. In contrast, levels 
      of HA, Ag KS, and MMP-3 did not change significantly in RA patients who had 
      remained in bed. Unlike the other markers, the levels of TIMP-1 remained 
      unchanged at the different time periods in all 3 groups studied. CONCLUSION: 
      Significant changes in serum levels of some metabolic markers occur during the 
      first hour after one arises from a night of sleep, especially in patients with 
      RA. Measurement of the magnitude of these changes at different times in 
      individual patients provides very different information about metabolic changes 
      occurring in joint tissue than does measurement of the level of the markers at a 
      single time point, as is usually currently reported.
FAU - Manicourt, D H
AU  - Manicourt DH
AD  - Saint-Luc University Hospital, Universite Catholique de Louvain, Brussels, 
      Belgium.
FAU - Poilvache, P
AU  - Poilvache P
FAU - Nzeusseu, A
AU  - Nzeusseu A
FAU - van Egeren, A
AU  - van Egeren A
FAU - Devogelaer, J P
AU  - Devogelaer JP
FAU - Lenz, M E
AU  - Lenz ME
FAU - Thonar, E J
AU  - Thonar EJ
LA  - eng
GR  - AG-04736/AG/NIA NIH HHS/United States
GR  - AR-39239/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (Antigens)
RN  - 0 (Biomarkers)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - 9056-36-4 (Keratan Sulfate)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Antigens/blood
MH  - Arthritis, Rheumatoid/*blood
MH  - Bed Rest
MH  - Biomarkers/blood
MH  - Exercise/physiology
MH  - Female
MH  - Humans
MH  - Hyaluronic Acid/*blood
MH  - Keratan Sulfate/*immunology
MH  - Kidney Function Tests
MH  - Liver Function Tests
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Time Factors
MH  - Tissue Inhibitor of Metalloproteinase-1/*blood
EDAT- 1999/10/08 00:00
MHDA- 1999/10/08 00:01
CRDT- 1999/10/08 00:00
PHST- 1999/10/08 00:00 [pubmed]
PHST- 1999/10/08 00:01 [medline]
PHST- 1999/10/08 00:00 [entrez]
AID - 10.1002/1529-0131(199909)42:9<1861::AID-ANR10>3.0.CO;2-I [doi]
PST - ppublish
SO  - Arthritis Rheum. 1999 Sep;42(9):1861-9. doi: 
      10.1002/1529-0131(199909)42:9<1861::AID-ANR10>3.0.CO;2-I.