PMID- 10515217
OWN - NLM
STAT- MEDLINE
DCOM- 19991104
LR  - 20191103
IS  - 0902-0063 (Print)
IS  - 0902-0063 (Linking)
VI  - 13
IP  - 5
DP  - 1999 Oct
TI  - Influence of hyperglycemia and hyperuricemia on long-term transplant survival in 
      kidney transplant recipients.
PG  - 375-9
AB  - Long-term prognosis in kidney transplant recipients depends on multiple factors. 
      The purpose of this study was to quantify the influence of hyperuricemia and 
      hyperglycemia (elements of the so-called 'syndrome X', i.e., a combination of 
      metabolic disorders like hyperuricemia, diabetes mellitus, hyperlipidemia, and 
      hypertension) on organ function in 350 kidney transplant recipients who had 
      received 375 kidney transplants up to 1990 and in whom sex, age of recipient and 
      donor, nephrologic disease, duration of dialysis, human leukocyte antigen (HLA) 
      classification, and duration of transplant ischemia had been well matched. We 
      found the influence of hyperuricemia on graft survival to be statistically 
      significant (p < or = 0.05), while a statistically significant correlation 
      between hyperglycemia and graft survival could not be detected in the present 
      study. The transplant survival rates 2, 4, and 5 yr post-kidney-transplantation 
      were 96.7, 80.7, and 78.7 in normogylcemic patients vs. 96.9, 85, and 82.7% in 
      hyperglycemic ( > 100 mg,dL) kidney transplant recipients (p > 0.05). Transplant 
      survival in hyperuricemic patients (male, > 8 mg dL; female, > 6.2 mg/dL) 2, 4, 
      and 5 yr post-transplantation was significantly reduced (92.2, 70.6, and 68.8% 
      vs. 98.1, 85.6, and 83.3%), as compared to normouricemic recipients. A combined 
      presence of both hyperuricemia and hyperglycemia probably influencing the 
      prognosis post-kidney-transplantation failed to reach the level of statistical 
      significance. We found a significant correlation between age of recipients and 
      plasma glucose (p < or = 0.01) and between serum uric acid concentrations and 
      diuretic therapy (p < or = 0.05) and gender (p < or = 0.(5). In conclusion, 
      hyperuricemia after kidney transplantation seems to reduce graft survival, 
      whereas an influence of the carbohydrate metabolism has to be denied.
FAU - Gerhardt, U
AU  - Gerhardt U
AD  - Medizinische Poliklinik, Universitat Munster, Germany.
FAU - Grosse Huttmann, M
AU  - Grosse Huttmann M
FAU - Hohage, H
AU  - Hohage H
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 268B43MJ25 (Uric Acid)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Creatinine/blood
MH  - Female
MH  - Follow-Up Studies
MH  - *Graft Survival
MH  - Humans
MH  - Hyperglycemia/*physiopathology
MH  - *Kidney Transplantation
MH  - Male
MH  - Prognosis
MH  - Uric Acid/*blood
EDAT- 1999/10/09 00:00
MHDA- 1999/10/09 00:01
CRDT- 1999/10/09 00:00
PHST- 1999/10/09 00:00 [pubmed]
PHST- 1999/10/09 00:01 [medline]
PHST- 1999/10/09 00:00 [entrez]
AID - 10.1034/j.1399-0012.1999.130502.x [doi]
PST - ppublish
SO  - Clin Transplant. 1999 Oct;13(5):375-9. doi: 10.1034/j.1399-0012.1999.130502.x.