PMID- 1051536
OWN - NLM
STAT- MEDLINE
DCOM- 19770315
LR  - 20141120
IS  - 0036-7672 (Print)
IS  - 0036-7672 (Linking)
VI  - 106
IP  - 49
DP  - 1976 Dec 4
TI  - [Pathogenicity of methicillin resistant Staphylococcus aureus. In vitro study].
PG  - 1751-4
AB  - Pathogenicity of methicillin-resistant (MR) strains of S. aureus is difficult to 
      determine from clinical or epidemiological data. The degree of their 
      pathogenicity has been tested in an in vitro phagocytic assay using isolated 
      polymorphonuclear leukocytes (PMN), since PMN are considered to be the main 
      defense mechanism against infections by S. aureus. In the phagocytic assay, 
      survival of MetR strains was measured simultaneously with that of a 
      methicillin-sensitive (MetS) control strain. After 30 and 60 min of incubation, 
      MetR strains survived the phagocytic action of PMN better than the MetS strain. 
      Amplification of resistance towards the antibiotic in three MetR strains did not 
      modify their survival in the phagocytic assay. In conclusion, MetR strains have a 
      definite pathogenic potential and this potential is not affected by the level of 
      resistance towards methicillin.
FAU - Vaudaux, P
AU  - Vaudaux P
FAU - Waldvogel, F A
AU  - Waldvogel FA
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Pouvoir pathogene de staphylocoques dores resistants a la methicilline.
PL  - Switzerland
TA  - Schweiz Med Wochenschr
JT  - Schweizerische medizinische Wochenschrift
JID - 0404401
RN  - Q91FH1328A (Methicillin)
SB  - IM
MH  - Humans
MH  - In Vitro Techniques
MH  - Methicillin/*pharmacology
MH  - Neutrophils/immunology
MH  - Penicillin Resistance
MH  - Phagocytosis
MH  - Staphylococcus aureus/drug effects/*pathogenicity
EDAT- 1976/12/04 00:00
MHDA- 1976/12/04 00:01
CRDT- 1976/12/04 00:00
PHST- 1976/12/04 00:00 [pubmed]
PHST- 1976/12/04 00:01 [medline]
PHST- 1976/12/04 00:00 [entrez]
PST - ppublish
SO  - Schweiz Med Wochenschr. 1976 Dec 4;106(49):1751-4.