PMID- 10515861
OWN - NLM
STAT- MEDLINE
DCOM- 19991122
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 94
IP  - 8
DP  - 1999 Oct 15
TI  - Monosomy 13 is associated with the transition of monoclonal gammopathy of 
      undetermined significance to multiple myeloma. Intergroupe Francophone du 
      Myelome.
PG  - 2583-9
AB  - Chromosomal abnormalities are present in most (if not all) patients with multiple 
      myeloma (MM) and primary plasma cell leukemia (PCL). Furthermore, recent data 
      have shown that numerical chromosomal changes are present in most individuals 
      with monoclonal gammopathy of undetermined significance (MGUS). Epidemiological 
      studies have shown that up to one third of MM may emerge from pre-existing MGUS. 
      To clarify further possible stepwise chromosomal aberrations on a pathway between 
      MGUS and MM, we have analyzed 158 patients with either MM or primary PCL and 19 
      individuals with MGUS using fluorescence in situ hybridization (FISH). Our FISH 
      analyses were designed to detect illegitimate IGH rearrangements at 14q32 or 
      monosomy 13. Whereas translocations involving the 14q32 region were observed with 
      a similar incidence (60%) in both conditions, a significant difference was found 
      in the incidence of monosomy 13 in MGUS versus MM or primary PCL. It was present 
      in 40% of MM/PCL patients, but in only 4 of 19 MGUS individuals. Moreover, 
      whereas monosomy 13 was found in the majority of plasma cells in MM, it was 
      observed only in cell subpopulations in MGUS. It is noteworthy that, in a group 
      of 20 patients with MM and a previous MGUS history, incidence of monosomy 13 was 
      70% versus 31% in MM patients without a known history of MGUS (P =.002). Thus, 
      this study highlights monosomy 13 as correlated with the transformation of MGUS 
      to overt MM and may define 2 groups of MM with possible different natural history 
      and outcome, ie, post-MGUS MM with a very high incidence of monosomy 13 and de 
      novo MM in which other genetic events might be involved. Serial analyses of 
      individuals with MGUS will be needed to validate this model.
FAU - Avet-Loiseau, H
AU  - Avet-Loiseau H
AD  - Laboratory of Hematology, the Clinical Hematology Department, Centre Hospitalier 
      Universitaire, Nantes, France. havetloiseau@chu-nantes.fr
FAU - Li, J Y
AU  - Li JY
FAU - Morineau, N
AU  - Morineau N
FAU - Facon, T
AU  - Facon T
FAU - Brigaudeau, C
AU  - Brigaudeau C
FAU - Harousseau, J L
AU  - Harousseau JL
FAU - Grosbois, B
AU  - Grosbois B
FAU - Bataille, R
AU  - Bataille R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Immunoglobulin Heavy Chains)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cell Transformation, Neoplastic/*genetics
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Disease Progression
MH  - Female
MH  - Genes, Immunoglobulin
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Plasma Cell/genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - *Monosomy
MH  - Multiple Myeloma/*genetics/pathology
MH  - Paraproteinemias/*genetics/pathology
MH  - Precancerous Conditions/*genetics/pathology
MH  - Prognosis
MH  - Recombination, Genetic
MH  - Translocation, Genetic
EDAT- 1999/10/09 00:00
MHDA- 1999/10/09 00:01
CRDT- 1999/10/09 00:00
PHST- 1999/10/09 00:00 [pubmed]
PHST- 1999/10/09 00:01 [medline]
PHST- 1999/10/09 00:00 [entrez]
AID - S0006-4971(20)71078-5 [pii]
PST - ppublish
SO  - Blood. 1999 Oct 15;94(8):2583-9.