PMID- 10516334
OWN - NLM
STAT- MEDLINE
DCOM- 20000531
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 20
DP  - 1999 Oct 15
TI  - Functional dichotomy within the vomeronasal system: distinct zones of neuronal 
      activity in the accessory olfactory bulb correlate with sex-specific behaviors.
PG  - RC32
AB  - Chemosensory neurons in the vomeronasal organ (VNO) detect pheromones that elicit 
      social and reproductive behaviors in most terrestrial vertebrates. Vomeronasal 
      receptor neurons are chemoarchitecturally divided into two populations based on 
      their position in the VNO, the type of G-protein subunit expressed, the family of 
      putative pheromone receptor expressed, and termination site of their axons in the 
      accessory olfactory bulb (AOB). To investigate the functional implications of 
      these two segregated VNO-AOB pathways, we stimulated mice with pheromonal cues 
      associated with different behavioral contexts and examined cellular activation 
      patterns in the AOB. Exposure of ICR male mice to BALB/c males resulted in 
      aggressive behavior, accompanied by a VNO-dependent increase in c-fos 
      immunoreactivity in a cluster of cells located almost exclusively in the caudal 
      AOB in both strains. This caudal cluster of activated cells did not appear to 
      require the overt display of aggressive behavior because it was present in both 
      the dominant and submissive males and could be evoked when the stimulus animal 
      was anesthetized. In contrast, exposure of an ICR male to an ICR female in 
      diestrus resulted in activation of cells located predominantly in the rostral 
      AOB. Our findings indicate that male-to-male interactions involving interstrain 
      recognition activate a separate population of vomeronasal receptor neurons than 
      chemosensory cues detected in a sexual context. The results suggest that the 
      dichotomy in the peripheral vomeronasal system serves to separate pheromones 
      based on the behaviors they drive. As such, the results provide a bioassay for 
      identifying pheromone molecules.
FAU - Kumar, A
AU  - Kumar A
AD  - University of Texas Southwestern Medical Center at Dallas, Department of 
      Physiology, Dallas, Texas 75235-9040, USA.
FAU - Dudley, C A
AU  - Dudley CA
FAU - Moss, R L
AU  - Moss RL
LA  - eng
GR  - MH41784/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Pheromones)
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
MH  - Aggression/physiology
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Female
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred ICR
MH  - Neurons/metabolism/*physiology
MH  - Olfactory Bulb/cytology/metabolism/*physiology
MH  - Pheromones/physiology
MH  - Proto-Oncogene Proteins c-fos/biosynthesis
MH  - Sex Characteristics
MH  - Sexual Behavior, Animal/physiology
MH  - Species Specificity
MH  - Vomeronasal Organ/*physiology
PMC - PMC6782749
EDAT- 1999/10/12 00:00
MHDA- 2000/06/03 00:00
PMCR- 2000/04/15
CRDT- 1999/10/12 00:00
PHST- 1999/10/12 00:00 [pubmed]
PHST- 2000/06/03 00:00 [medline]
PHST- 1999/10/12 00:00 [entrez]
PHST- 2000/04/15 00:00 [pmc-release]
AID - 3549 [pii]
AID - 10.1523/JNEUROSCI.19-20-j0003.1999 [doi]
PST - ppublish
SO  - J Neurosci. 1999 Oct 15;19(20):RC32. doi: 10.1523/JNEUROSCI.19-20-j0003.1999.