PMID- 10516431
OWN - NLM
STAT- MEDLINE
DCOM- 19991027
LR  - 20171101
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 86
IP  - 1
DP  - 1999
TI  - Nondisjunction in human sperm: comparison of frequencies in acrocentric 
      chromosomes.
PG  - 43-5
AB  - Acrocentric chromosomes may be particularly predisposed to nondisjunction because 
      of the frequency of trisomy for these chromosomes in human spontaneous abortions 
      and liveborns. Studies of aneuploidy in human sperm have provided data on only a 
      few acrocentric chromosomes, with evidence that chromosome 21 has a significantly 
      increased frequency of disomy. To determine whether other acrocentric chromosomes 
      have a higher frequency of nondisjunction or if chromosome 21 is anomalous, 
      disomy frequencies for chromosomes 13 and 22 were studied by fluorescence in situ 
      hybridization (FISH) analysis of 51,043 sperm nuclei from five normal men for 
      whom the frequency of disomy for chromosomes 15 and 21 was known. The mean 
      frequency of disomy for chromosome 13 (0.19%) did not differ significantly from 
      that for other autosomes; however, the frequency of disomy 22 (1.21%) was 
      significantly elevated (P < 0.001, Mantel-Haenszel chi(2) test). The G-group 
      chromosomes (Nos. 21 and 22) also showed a significantly increased frequency of 
      disomy (0. 75%) compared to acrocentric D-group chromosomes (viz., chromosomes 13 
      and 15; 0.15%) (P < 0.001, Mantel-Haenszel chi(2) test) and other autosomes 
      (chromosomes 1, 2, 4, 9, 12, 13, 15, 16, 18, and 20; 0. 13%) studied in the same 
      men (P < 0.001, Mantel-Haenszel chi(2) test).
FAU - Martin, R H
AU  - Martin RH
AD  - Department of Medical Genetics, University of Calgary, Alberta Children's 
      Hospital, Calgary, Alberta, Canada. renee@ach.ucalgary.ca
FAU - Rademaker, A W
AU  - Rademaker AW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
SB  - IM
MH  - *Aneuploidy
MH  - Cell Count
MH  - Chromosomes, Human/*genetics
MH  - Chromosomes, Human, Pair 13/genetics
MH  - Chromosomes, Human, Pair 22/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - *Nondisjunction, Genetic
MH  - Spermatozoa/*cytology/metabolism
EDAT- 1999/10/12 00:00
MHDA- 1999/10/12 00:01
CRDT- 1999/10/12 00:00
PHST- 1999/10/12 00:00 [pubmed]
PHST- 1999/10/12 00:01 [medline]
PHST- 1999/10/12 00:00 [entrez]
AID - 15427 [pii]
AID - 10.1159/000015427 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1999;86(1):43-5. doi: 10.1159/000015427.