PMID- 10517113
OWN - NLM
STAT- MEDLINE
DCOM- 19991119
LR  - 20131121
IS  - 0040-5930 (Print)
IS  - 0040-5930 (Linking)
VI  - 56
IP  - 9
DP  - 1999 Sep
TI  - [Recurrent thromboembolisms despite oral anticoagulation in a 76-year-old 
      patient--Trousseau syndrome].
PG  - 481-3
AB  - We report the case of a 76-year-old man with recurrent thromboses and low-grade 
      chronic disseminated intravascular coagulation despite therapeutic oral 
      anticoagulation with phenprocoumon. Work-up revealed a bronchial carcinoma 
      (NSCCL) with hilar and mediastinal lymph node metastasis. The clinical condition 
      was consistent with Trousseau's syndrome. Based on reports in the literature, the 
      therapy was changed from phenprocoumon to intravenous unfractionated heparin 
      (UFH), which was effective in controlling the thrombotic coagulopathy. For 
      practical reasons, despite lack of established effectiveness in Trousseau's 
      syndrome, therapy was switched to low-molecular-weight heparin (LMWH, 
      nadroparine) in therapeutic dosage of 100 IU/kg body wt. subcutaneously 12 
      hourly. The patient remained free from further thromboembolic events during the 
      last 6.5 months of his life. This case suggests that LMWH might be a convenient 
      alternative to the established therapy with UFH in Trousseau's syndrome.
FAU - Zuger, M
AU  - Zuger M
AD  - Zentrallaboratorien Thurgauische Kantonsspitaler, Munsterlingen.
FAU - Demarmels Biasiutti, F
AU  - Demarmels Biasiutti F
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Rezidivierende Thromboembolien trotz oraler Antikoagulation bei einem 76jahrigen 
      Patienten--Trousseau Syndrom.
PL  - Switzerland
TA  - Ther Umsch
JT  - Therapeutische Umschau. Revue therapeutique
JID - 0407224
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
RN  - Q08SIO485D (Phenprocoumon)
SB  - IM
MH  - Aged
MH  - Anticoagulants/*administration & dosage
MH  - Carcinoma, Non-Small-Cell Lung/blood/*diagnosis/drug therapy
MH  - Heparin/administration & dosage
MH  - Heparin, Low-Molecular-Weight/administration & dosage
MH  - Humans
MH  - Injections, Subcutaneous
MH  - Lung Neoplasms/blood/*diagnosis/drug therapy
MH  - Male
MH  - Paraneoplastic Syndromes/blood/*diagnosis/drug therapy
MH  - Phenprocoumon/*administration & dosage
MH  - Recurrence
MH  - Thromboembolism/blood/*diagnosis/drug therapy
EDAT- 1999/10/12 00:00
MHDA- 1999/10/12 00:01
CRDT- 1999/10/12 00:00
PHST- 1999/10/12 00:00 [pubmed]
PHST- 1999/10/12 00:01 [medline]
PHST- 1999/10/12 00:00 [entrez]
AID - 10.1024/0040-5930.56.9.481 [doi]
PST - ppublish
SO  - Ther Umsch. 1999 Sep;56(9):481-3. doi: 10.1024/0040-5930.56.9.481.