PMID- 10517560
OWN - NLM
STAT- MEDLINE
DCOM- 19991201
LR  - 20190513
IS  - 0146-4760 (Print)
IS  - 0146-4760 (Linking)
VI  - 23
IP  - 6
DP  - 1999 Oct
TI  - Simultaneous determination of amphetamine, methamphetamine, 
      methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), and 
      methylenedioxyethylamphetamine (MDEA) enantiomers by GC-MS.
PG  - 518-23
AB  - A method is described for the simultaneous determination of the ratio of l- and 
      d-enantiomers of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine 
      (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 
      3,4-methylenedioxyethylamphetamine (MDEA) in urine. The assay uses liquid-liquid 
      extraction followed by derivatization with trifluoroacetyl-l-prolyl chloride 
      (l-TPC) and analysis by gas chromatography-mass spectrometry. The assay was 
      developed using prepared samples containing varying concentrations of each of the 
      analytes over a range of percentages of each enantiomer. Results showed the 
      method to provide accurate and reliable results in samples containing > or = 10 
      ng/mL amphetamine and methamphetamine and > or = 25 ng/mL MDA, MDMA, and MDEA. 
      The assay was used to analyze urine samples from subjects of a controlled MDMA 
      study. Results for each of the eight subjects showed a greater percentage of the 
      l-enantiomer of MDMA initially, and the percentage increased with time postdose. 
      Analysis of the metabolite MDA revealed that the proportion of d-enantiomer was 
      initially greater than the l-enantiomer followed by a gradual increase in the 
      proportion of l-enantiomer until it exceeded the amount of the d-enantiomer. In 
      all cases, the l-MDA exceeded the d-MDA within the first 36 h postdose.
FAU - Hensley, D
AU  - Hensley D
AD  - Clinical Research Squadron, Wilford Hall Medical Center, Lackland AFB, Texas 
      78236-5319, USA.
FAU - Cody, J T
AU  - Cody JT
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 0 (Amphetamines)
RN  - 0 (Central Nervous System Stimulants)
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - ML1I4KK67B (3,4-methylenedioxyethamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/urine
MH  - Amphetamines/*urine
MH  - Central Nervous System Stimulants/*urine
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - In Vitro Techniques
MH  - Methamphetamine/urine
MH  - N-Methyl-3,4-methylenedioxyamphetamine/urine
MH  - Sensitivity and Specificity
MH  - Stereoisomerism
MH  - Substance Abuse Detection/*methods
MH  - Time Factors
MH  - Urine/*chemistry
EDAT- 1999/10/12 00:00
MHDA- 1999/10/12 00:01
CRDT- 1999/10/12 00:00
PHST- 1999/10/12 00:00 [pubmed]
PHST- 1999/10/12 00:01 [medline]
PHST- 1999/10/12 00:00 [entrez]
AID - 10.1093/jat/23.6.518 [doi]
PST - ppublish
SO  - J Anal Toxicol. 1999 Oct;23(6):518-23. doi: 10.1093/jat/23.6.518.