PMID- 10517960
OWN - NLM
STAT- MEDLINE
DCOM- 19991122
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 840
IP  - 1-2
DP  - 1999 Sep 4
TI  - Learning abilities, NGF and BDNF brain levels in two lines of TNF-alpha 
      transgenic mice, one characterized by neurological disorders, the other 
      phenotypically normal.
PG  - 125-37
AB  - In this study we used two lines of transgenic mice overexpressing tumor necrosis 
      factor alpha (TNF-alpha) in the central nervous system (CNS), one characterized 
      by reactive gliosis, inflammatory demyelination and neurological deficits 
      (Tg6074) the other showing no neurological or phenotypical alterations (TgK3) to 
      investigate the effect of TNF-alpha on brain nerve growth factor (NGF) and 
      brain-derived neurotrophic factor (BDNF) levels and learning abilities. The 
      results showed that the amount of NGF in the brain of Tg6074 and TgK3 transgenic 
      mice is low in the hippocampus and in the spinal cord, increases in the 
      hypothalamus of Tg6074 and showed no significant changes in the cortex. BDNF 
      levels were low in the hippocampus and spinal cord of TgK3. BDNF increased in the 
      hypothalamus of TgK3 and Tg6074 while in the cortex, BDNF increased only in 
      Tg6074 mice. Transgenic mice also had memory impairments as revealed by the 
      Morris Water Maze test. These findings indicate that TNF-alpha significantly 
      influences BDNF and NGF synthesis, most probably in a dose-dependent manner. 
      Learning abilities were also differently affected by overexpression of TNF-alpha, 
      but were not associated with inflammatory activity. The possible functional 
      implications of our findings are discussed.
FAU - Aloe, L
AU  - Aloe L
AD  - Institute of Neurobiology, CNR, viale Marx, 43-15, 00137, Rome, Italy. 
      aloe@in.rm.cnr.it
FAU - Properzi, F
AU  - Properzi F
FAU - Probert, L
AU  - Probert L
FAU - Akassoglou, K
AU  - Akassoglou K
FAU - Kassiotis, G
AU  - Kassiotis G
FAU - Micera, A
AU  - Micera A
FAU - Fiore, M
AU  - Fiore M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Maze Learning/*drug effects
MH  - Mice
MH  - Mice, Inbred Strains/genetics
MH  - Mice, Transgenic/genetics
MH  - Nerve Growth Factor/*metabolism
MH  - Nervous System Diseases/genetics/*metabolism
MH  - Reference Values
MH  - Tumor Necrosis Factor-alpha/genetics/*pharmacology
EDAT- 1999/10/13 00:00
MHDA- 1999/10/13 00:01
CRDT- 1999/10/13 00:00
PHST- 1999/10/13 00:00 [pubmed]
PHST- 1999/10/13 00:01 [medline]
PHST- 1999/10/13 00:00 [entrez]
AID - S0006-8993(99)01748-5 [pii]
AID - 10.1016/s0006-8993(99)01748-5 [doi]
PST - ppublish
SO  - Brain Res. 1999 Sep 4;840(1-2):125-37. doi: 10.1016/s0006-8993(99)01748-5.