PMID- 10518744
OWN - NLM
STAT- MEDLINE
DCOM- 19991117
LR  - 20181130
IS  - 0378-1097 (Print)
IS  - 0378-1097 (Linking)
VI  - 179
IP  - 2
DP  - 1999 Oct 15
TI  - Characterization of the integration site of Yersinia high-pathogenicity island in 
      Escherichia coli.
PG  - 409-14
AB  - The high-pathogenicity island (HPI) of virulent Yersiniae consists of (i) a 
      functional core encoding for biosynthesis and uptake of the siderophore 
      yersiniabactin and (ii) a 5- to 13-kb AT-rich region of unknown function. This 
      Yersinia HPI has been shown to be widely distributed among different pathotypes 
      of Escherichia coli. In this study, the insertion site of the HPI was defined in 
      three different E. coli strains: The enteroaggregative E. coli (EAggEC) strain 
      17-2, the uropathogenic (UPEC) E. coli strain 536, and the probiotic E. coli 
      DSM6601. We demonstrated that in all three E. coli isolates the HPI is associated 
      with the asnT tRNA (5'-extremity) and truncated in the AT-rich region 
      (3'-extremity) since the 17-bp direct repeat (DR) of the asn tRNA that flanks the 
      HPI in Yersinia is missing in E. coli. Moreover, in comparison to the 
      HPI-negative E. coli K-12 strain, a uniform deletion must have taken place in the 
      E. coli chromosome adjacent to the 3'-border of the HPI.
FAU - Schubert, S
AU  - Schubert S
AD  - Max von Pettenkofer-Institut, Pettenkoferstr. 9a, 80336, Munchen, Germany.
FAU - Rakin, A
AU  - Rakin A
FAU - Fischer, D
AU  - Fischer D
FAU - Sorsa, J
AU  - Sorsa J
FAU - Heesemann, J
AU  - Heesemann J
LA  - eng
SI  - GENBANK/AF135406
SI  - GENBANK/AF136296
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEMS Microbiol Lett
JT  - FEMS microbiology letters
JID - 7705721
SB  - IM
MH  - Escherichia coli/*genetics
MH  - *Genes, Bacterial
MH  - Virulence/genetics
MH  - Yersinia/*genetics/*pathogenicity
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - S0378-1097(99)00442-5 [pii]
AID - 10.1111/j.1574-6968.1999.tb08756.x [doi]
PST - ppublish
SO  - FEMS Microbiol Lett. 1999 Oct 15;179(2):409-14. doi: 
      10.1111/j.1574-6968.1999.tb08756.x.