PMID- 10520793
OWN - NLM
STAT- MEDLINE
DCOM- 19991027
LR  - 20190708
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 34
IP  - 4
DP  - 1999 Oct
TI  - Coronary artery distensibility in diabetic patients with simultaneous 
      measurements of luminal area and intracoronary pressure: evidence of impaired 
      reactivity to nitroglycerin.
PG  - 1075-81
AB  - OBJECTIVES: This study investigated whether noninsulin dependent diabetes 
      mellitus (NIDDM) adversely affects the elastic properties of the coronary 
      arteries in patients with coronary artery disease (CAD) and NIDDM. BACKGROUND: 
      Attenuated vascular smooth muscle dilation to exogenous donors of nitric oxide, 
      such as nitroglycerin, has been observed with forearm blood flow studies in 
      patients with NIDDM. METHODS: Twenty patients with CAD and NIDDM (diabetics), and 
      20 patients with only CAD (nondiabetics) were evaluated. Intracoronary ultrasound 
      (ICUS) imaging with simultaneous intracoronary pressure (P2) recordings were 
      performed at the imaging site with 0.014 in fiber-optic high fidelity pressure 
      monitoring wire. The same wire was used as guide wire for the ICUS catheter. 
      Sites with less than 50% luminal stenosis by ICUS were studied. Recordings were 
      done before and after 300 microg of intracoronary nitroglycerin (IC-NTG). 
      Electrocardiographic tracings recorded simultaneously with ICUS images were used 
      for timing. Systolic and diastolic cross-sectional lumen area (CSLA) and coronary 
      artery distensibility (C-DIST) were measured, C-DIST = [(systolic CSLA-diastolic 
      CSLA)/[(intracoronary pulse pressure) x (diastolic CSLA)]] x 1,000. RESULTS: 
      Diabetics had smaller CSLA (diabetics = 8.6 +/- 0.6 mm2, nondiabetics = 11.5 +/- 
      0.5 mm2, p < 0.01). Although C-DIST was similar before IC-NTG in the two groups, 
      it became significantly lower in diabetics after IC-NTG (diabetics C-DIST = 3.02 
      +/- 0.14 mm Hg(-1), nondiabetics C-DIST = 4.21 +/- 0.15 mm Hg(-1), p < 0.01). 
      Degrees of circumference involved, total plaque burden and composition were 
      similar in both groups. CONCLUSIONS: Noninsulin dependent diabetes mellitus 
      reduces C-DIST after IC-NTG administration.
FAU - Vavuranakis, M
AU  - Vavuranakis M
AD  - Department of Cardiology, Hipprokration Hospital, University of Athens, Greece.
FAU - Stefanadis, C
AU  - Stefanadis C
FAU - Triandaphyllidi, E
AU  - Triandaphyllidi E
FAU - Toutouzas, K
AU  - Toutouzas K
FAU - Toutouzas, P
AU  - Toutouzas P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
RN  - 0 (Vasodilator Agents)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - G59M7S0WS3 (Nitroglycerin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Pressure/*physiology
MH  - Cardiac Catheterization/instrumentation
MH  - Coronary Disease/diagnostic imaging/*physiopathology
MH  - Coronary Vessels/*physiology
MH  - Diabetes Mellitus, Type 2/diagnostic imaging/*physiopathology
MH  - Diabetic Angiopathies/diagnostic imaging/*physiopathology
MH  - Diastole/physiology
MH  - Elasticity
MH  - Electrocardiography
MH  - *Endosonography/instrumentation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/physiology
MH  - Nitroglycerin
MH  - Observer Variation
MH  - Systole/physiology
MH  - Vasodilation/*physiology
MH  - Vasodilator Agents
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - S0735-1097(99)00331-9 [pii]
AID - 10.1016/s0735-1097(99)00331-9 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 1999 Oct;34(4):1075-81. doi: 10.1016/s0735-1097(99)00331-9.