PMID- 10521588
OWN - NLM
STAT- MEDLINE
DCOM- 19991223
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 71
IP  - 2
DP  - 1999 Aug 25
TI  - Negative regulation of brain-derived neurotrophic factor mRNA expression by 
      kainic acid in substantia nigra.
PG  - 341-4
AB  - By using in situ hybridization, we have demonstrated that kainic acid (KA) 
      administration decreases brain-derived neurotrophic factor (BDNF) mRNA expression 
      in the substantia nigra pars compacta of adult rat. In addition, RT-PCR analysis 
      indicated that transcripts derived from exons 1a and 1c of the BDNF gene were 
      strongly decreased after KA treatment. Conversely, in dentate gyrus this 
      treatment increased the expression of BDNF mRNAs derived from exons 1b, 1c and 
      1d. Our data show, contrarily to what is observed in most brain structures, that 
      KA exerts a negative regulatory effect on BDNF mRNA expression in the adult 
      substantia nigra.
FAU - Aliaga, E
AU  - Aliaga E
AD  - Laboratorio de Farmacologia-Bioquimica, Facultad de Ciencias Biologicas, 
      Pontificia Universidad Catolica de Chile, Alameda 340, P.O. Box 114-D, Santiago, 
      Chile.
FAU - Rage, F
AU  - Rage F
FAU - Tapia-Arancibia, L
AU  - Tapia-Arancibia L
FAU - Bustos, G
AU  - Bustos G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (RNA, Messenger)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Excitatory Amino Acid Agonists/*pharmacology
MH  - Gene Expression Regulation/*drug effects
MH  - In Situ Hybridization
MH  - Kainic Acid/*pharmacology
MH  - Male
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Substantia Nigra/drug effects/*metabolism
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - S0169328X9900159X [pii]
AID - 10.1016/s0169-328x(99)00159-x [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 1999 Aug 25;71(2):341-4. doi: 
      10.1016/s0169-328x(99)00159-x.