PMID- 10522904
OWN - NLM
STAT- MEDLINE
DCOM- 19991217
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 53
IP  - 6
DP  - 1999 Oct 12
TI  - Primary association of a TNF gene polymorphism with susceptibility to multiple 
      sclerosis.
PG  - 1361-3
AB  - The associations of three promoter polymorphisms in the tumor necrosis factor 
      (TNFA) gene have been studied in 238 patients and 324 control subjects. A 
      significant correlation was found between MS susceptibility and the TNFA-376 
      polymorphism. This association was independent of the human leukocyte antigen 
      (HLA) class II association and the combined inheritance of HLA-DRB1*1501 and the 
      TNFA-376A allele more than additively increased susceptibility to MS.
FAU - Fernandez-Arquero, M
AU  - Fernandez-Arquero M
AD  - Department of Immunology, San Carlos University Hospital, Madrid, Spain.
FAU - Arroyo, R
AU  - Arroyo R
FAU - Rubio, A
AU  - Rubio A
FAU - Martin, C
AU  - Martin C
FAU - Vigil, P
AU  - Vigil P
FAU - Conejero, L
AU  - Conejero L
FAU - Figueredo, M A
AU  - Figueredo MA
FAU - de la Concha, E G
AU  - de la Concha EG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Alleles
MH  - Genotype
MH  - Humans
MH  - Multiple Sclerosis/*genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - 10.1212/wnl.53.6.1361 [doi]
PST - ppublish
SO  - Neurology. 1999 Oct 12;53(6):1361-3. doi: 10.1212/wnl.53.6.1361.