PMID- 10522991
OWN - NLM
STAT- MEDLINE
DCOM- 19991104
LR  - 20131121
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 84
IP  - 10
DP  - 1999 Oct
TI  - Plasma cholesterol esterification and transfer, the menopause, and hormone 
      replacement therapy in women.
PG  - 3534-8
AB  - With the onset of the menopause, plasma lipids and lipoprotein metabolism changes 
      toward a more atherogenic profile that is improved by HRT. To determine whether 
      cholesterol esterification rate (CER) and transfer of cholesteryl esters from 
      high density lipoproteins to apolipoprotein B-containing lipoproteins are 
      affected by menopause and HRT, plasma newly synthesized cholesteryl ester 
      transfer (NCET) activity, CER and plasma lipids, lipoproteins, and apolipoprotein 
      concentrations were measured in perimenopausal women (age range: 40-55 yr), 
      including 49 premenopausal women and 32 postmenopausal women who were 
      subsequently randomized to receive either placebo or 17-beta 
      estradiol/norethisterone for 6 months. Plasma NCET (P = 0.03) and CER (P = 0.008) 
      were significantly higher in postmenopausal women. Plasma low density lipoprotein 
      cholesterol concentration, high density lipoprotein concentration, and body mass 
      index were independent predictors of plasma NCET in premenopausal women, and 
      plasma triglyceride and apolipoprotein B concentrations were corresponding 
      predictors in postmenopausal women. When data were adjusted for plasma 
      triglyceride, plasma NCET activity was no longer significantly different (P = 
      0.81) between premenopausal and postmenopausal women. Plasma NCET and CER did not 
      change significantly in postmenopausal women during HRT. These data suggest that 
      the determinants of plasma NCET activity after menopause and increased levels of 
      triglyceride-rich lipoprotein acceptors of cholesteryl esters may lead to 
      increased plasma NCET that is not reduced by HRT in postmenopausal women.
FAU - Lewis-Barned, N J
AU  - Lewis-Barned NJ
AD  - Department of Endocrinology and Diabetes, Gloucestershire Royal Hospital, 
      Gloucester, United Kingdom.
FAU - Sutherland, W H
AU  - Sutherland WH
FAU - Walker, R J
AU  - Walker RJ
FAU - Walker, H L
AU  - Walker HL
FAU - De Jong, S A
AU  - De Jong SA
FAU - Edwards, E A
AU  - Edwards EA
FAU - Markham, V H
AU  - Markham VH
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (CETP protein, human)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cholesterol Ester Transfer Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Lipids)
RN  - 0 (Progesterone Congeners)
RN  - 4TI98Z838E (Estradiol)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - T18F433X4S (Norethindrone)
SB  - IM
MH  - Adult
MH  - Carrier Proteins/*blood
MH  - Cholesterol/*blood/metabolism
MH  - Cholesterol Ester Transfer Proteins
MH  - Cross-Sectional Studies
MH  - Esterification
MH  - Estradiol/therapeutic use
MH  - *Estrogen Replacement Therapy
MH  - Female
MH  - *Glycoproteins
MH  - Humans
MH  - Lipids/blood
MH  - Menopause/*blood
MH  - Middle Aged
MH  - Norethindrone/therapeutic use
MH  - Postmenopause/blood
MH  - Premenopause/blood
MH  - Progesterone Congeners/therapeutic use
MH  - Single-Blind Method
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - 10.1210/jcem.84.10.6022 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1999 Oct;84(10):3534-8. doi: 10.1210/jcem.84.10.6022.