PMID- 10523002
OWN - NLM
STAT- MEDLINE
DCOM- 19991104
LR  - 20131121
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 84
IP  - 10
DP  - 1999 Oct
TI  - A possible role of immunoglobulin E in patients with hyperthyroid Graves' 
      disease.
PG  - 3602-5
AB  - To investigate the possible participation of immunoglobulin E (IgE) in the 
      autoimmune process of Graves' disease, incidence of elevation of serum IgE level, 
      TSH receptor antibody (TRAb), and thyroid status were studied in 66 patients with 
      hyperthyroid Graves' disease, 54 patients with Hashimoto's thyroiditis, 19 
      patients with bronchial asthma, and 15 patients with pollen allergy. In 
      hyperthyroid Graves' patients, elevation of serum IgE levels (> or = 170 U/mL) 
      was found in 19 of 66 patients (29%), 11 of whom had hereditary and/or allergic 
      conditions. Elevations of serum IgE levels were found in 63% of patients with 
      bronchial asthma and in 40% of patients with pollen allergy. Mean values of serum 
      IgE were the same in patients with hyperthyroid Graves' disease and with 
      bronchial asthma. During methimazole treatment TRAb decreased without fluctuation 
      of IgE levels in both groups. The decrease in TRAb was significantly greater in 
      patients with normal IgE than in patients with IgE elevation. After prednisone 
      administration, reduction in TRAb was greater in patients with normal IgE than 
      that in patients with IgE elevation. High incidence of IgE elevation in 
      hyperthyroid Graves' disease and slower reduction in TRAb in association with IgE 
      elevation suggest a difference in the autoimmune processes in Graves' disease 
      with and without elevation of IgE.
FAU - Sato, A
AU  - Sato A
AD  - Department of Medicine, Dokkyo Koshigaya Hospital, Dokkyo University School of 
      Medicine, Saitama, Japan.
FAU - Takemura, Y
AU  - Takemura Y
FAU - Yamada, T
AU  - Yamada T
FAU - Ohtsuka, H
AU  - Ohtsuka H
FAU - Sakai, H
AU  - Sakai H
FAU - Miyahara, Y
AU  - Miyahara Y
FAU - Aizawa, T
AU  - Aizawa T
FAU - Terao, A
AU  - Terao A
FAU - Onuma, S
AU  - Onuma S
FAU - Junen, K
AU  - Junen K
FAU - Kanamori, A
AU  - Kanamori A
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Tejima, E
AU  - Tejima E
FAU - Ito, Y
AU  - Ito Y
FAU - Kamijo, K
AU  - Kamijo K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Antithyroid Agents)
RN  - 0 (Glucocorticoids)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 554Z48XN5E (Methimazole)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antithyroid Agents/therapeutic use
MH  - Asthma/blood/drug therapy
MH  - Female
MH  - Glucocorticoids/therapeutic use
MH  - Graves Disease/blood/drug therapy/*physiopathology
MH  - Humans
MH  - Hypersensitivity/blood/drug therapy
MH  - Immunoglobulin E/blood/*physiology
MH  - Male
MH  - Methimazole/therapeutic use
MH  - Middle Aged
MH  - Pollen/immunology
MH  - Prednisone/therapeutic use
MH  - Thyroid Diseases/blood/drug therapy/physiopathology
MH  - Thyroid Gland/drug effects/physiopathology
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - 10.1210/jcem.84.10.6038 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1999 Oct;84(10):3602-5. doi: 10.1210/jcem.84.10.6038.