PMID- 10523539
OWN - NLM
STAT- MEDLINE
DCOM- 19991130
LR  - 20200724
IS  - 0095-1137 (Print)
IS  - 1098-660X (Electronic)
IS  - 0095-1137 (Linking)
VI  - 37
IP  - 11
DP  - 1999 Nov
TI  - Detection of specific immunoglobulin E during maternal, fetal, and congenital 
      toxoplasmosis.
PG  - 3487-90
AB  - Toxoplasma immunoglobulin E (IgE) antibodies in 664 serum samples were evaluated 
      by using an immunocapture method with a suspension of tachyzoites prepared in the 
      laboratory in order to evaluate its usefulness in the diagnosis of acute 
      Toxoplasma gondii infection during pregnancy, congenital infection, and 
      progressive toxoplasmosis. IgE antibodies were never detected in sera from 
      seronegative women, from patients with chronic toxoplasma infection, or from 
      infants without congenital toxoplasmosis. In contrast, they were detected in 
      86.6% of patients with toxoplasmic seroconversion, and compared with IgA and IgM, 
      the short kinetics of IgE was useful to date the infection precisely. For the 
      diagnosis of congenital toxoplasmosis, specific IgE detected was less frequently 
      than IgM or IgA (25 versus 67.3%), but its detection during follow-up of children 
      may be interesting, reflecting an immunological rebound. Finally, IgE was 
      detected early and persisted longer in progressive toxoplasmosis with cervical 
      adenopathies, so it was also a good marker of the evolution of toxoplasma 
      infection.
FAU - Villena, I
AU  - Villena I
AD  - Laboratory of Parasitology-Mycology, Team 4 (INSERM U.314), EA 2070, IFR 53, 
      Hopital Maison Blanche, Reims, France. ivillena@chu-reims.fr
FAU - Aubert, D
AU  - Aubert D
FAU - Brodard, V
AU  - Brodard V
FAU - Quereux, C
AU  - Quereux C
FAU - Leroux, B
AU  - Leroux B
FAU - Dupouy, D
AU  - Dupouy D
FAU - Remy, G
AU  - Remy G
FAU - Foudrinier, F
AU  - Foudrinier F
FAU - Chemla, C
AU  - Chemla C
FAU - Gomez-Marin, J E
AU  - Gomez-Marin JE
FAU - Pinon, J M
AU  - Pinon JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Microbiol
JT  - Journal of clinical microbiology
JID - 7505564
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin M)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Protozoan/*blood
MH  - Antibody Specificity
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Chorioretinitis/diagnosis/immunology
MH  - Female
MH  - Fetal Blood/immunology
MH  - Humans
MH  - Immunoglobulin A/blood
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin M/blood
MH  - Infant
MH  - Infant, Newborn
MH  - Infectious Disease Transmission, Vertical
MH  - Middle Aged
MH  - Pregnancy
MH  - Pregnancy Complications, Parasitic/diagnosis/*immunology
MH  - Time Factors
MH  - Toxoplasmosis/*complications/diagnosis/*immunology
MH  - Toxoplasmosis, Congenital/diagnosis/immunology
MH  - Toxoplasmosis, Ocular/diagnosis/immunology
PMC - PMC85675
EDAT- 1999/10/19 00:00
MHDA- 1999/10/19 00:01
PMCR- 1999/11/01
CRDT- 1999/10/19 00:00
PHST- 1999/10/19 00:00 [pubmed]
PHST- 1999/10/19 00:01 [medline]
PHST- 1999/10/19 00:00 [entrez]
PHST- 1999/11/01 00:00 [pmc-release]
AID - 0464 [pii]
AID - 10.1128/JCM.37.11.3487-3490.1999 [doi]
PST - ppublish
SO  - J Clin Microbiol. 1999 Nov;37(11):3487-90. doi: 10.1128/JCM.37.11.3487-3490.1999.