PMID- 10523816
OWN - NLM
STAT- MEDLINE
DCOM- 19991210
LR  - 20191103
IS  - 1359-4184 (Print)
IS  - 1359-4184 (Linking)
VI  - 4
IP  - 5
DP  - 1999 Sep
TI  - Radiation hybrid mapping of genes in the lithium-sensitive wnt signaling pathway.
PG  - 437-42
AB  - Lithium, an effective drug in the treatment of bipolar disorder, has been 
      proposed to disrupt the Wnt signaling pathway. To facilitate analysis of the 
      possible involvement of elements of the Wnt pathway in human bipolar disorder, a 
      high resolution radiation hybrid mapping (RHM) of these genes was performed. A 
      fine physical location has been obtained for Wnt 7A, frizzled 3, 4 and 5, 
      dishevelled 1, 2 and 3, GSK3beta, axin, alpha-catenin, the Armadillo 
      repeat-containing genes (delta-catenin and ARVCF), and a frizzled-like protein 
      (frpHE) using the Stanford Human Genome Center (SHGC) G3 panel. Most of these 
      genes were previously mapped by fluorescence in situ hybridization (FISH). 
      Frizzled 4, axin and frpHE did not have a previous chromosomal assignment and 
      were linked by RHM to chromosome markers, SHGC-35131 at 11q22.1, NIB1488 at 
      16p13.3 and D7S2919 at 7p15.2, respectively. Interestingly, some of these genes 
      were found to map within potential regions underlying susceptibility to bipolar 
      disorder and schizophrenia as well as disorders of neurodevelopmental origin. 
      This alternative approach of establishing the precise location of selected 
      genetic components of a candidate pathway and determining if they map within 
      previously defined susceptibility loci should help to identify plausible 
      candidate genes that warrant further analysis through association and mutational 
      scanning.
FAU - Rhoads, A R
AU  - Rhoads AR
AD  - Department of Biochemistry and Molecular Biology, Howard University, Washington, 
      DC 20059, USA.
FAU - Karkera, J D
AU  - Karkera JD
FAU - Detera-Wadleigh, S D
AU  - Detera-Wadleigh SD
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Antimanic Agents)
RN  - 0 (Axin Protein)
RN  - 0 (CTNNA1 protein, human)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (DNA Primers)
RN  - 0 (DVL1 protein, human)
RN  - 0 (Desmoplakins)
RN  - 0 (Dishevelled Proteins)
RN  - 0 (FZD3 protein, human)
RN  - 0 (Frizzled Receptors)
RN  - 0 (Phosphoproteins)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Repressor Proteins)
RN  - 0 (WNT7A protein, human)
RN  - 0 (Wnt Proteins)
RN  - 0 (alpha Catenin)
RN  - 9FN79X2M3F (Lithium)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.26 (Glycogen Synthase Kinase 3)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Antimanic Agents/*pharmacology
MH  - Axin Protein
MH  - Bipolar Disorder/*drug therapy/*genetics
MH  - Calcium-Calmodulin-Dependent Protein Kinases/genetics
MH  - Chromosome Mapping/methods
MH  - Cricetinae
MH  - Cytoskeletal Proteins/genetics
MH  - DNA Primers
MH  - Desmoplakins
MH  - Dishevelled Proteins
MH  - Frizzled Receptors
MH  - Genetic Predisposition to Disease
MH  - Genome, Human
MH  - Glycogen Synthase Kinase 3
MH  - Humans
MH  - Lithium/*pharmacology
MH  - Phosphoproteins/genetics
MH  - Proteins/genetics
MH  - Proto-Oncogene Proteins/*genetics
MH  - Radiation Chimera
MH  - Receptors, Cell Surface/genetics
MH  - *Receptors, G-Protein-Coupled
MH  - *Repressor Proteins
MH  - Signal Transduction/*drug effects
MH  - Wnt Proteins
MH  - alpha Catenin
EDAT- 1999/10/19 00:00
MHDA- 1999/10/19 00:01
CRDT- 1999/10/19 00:00
PHST- 1999/10/19 00:00 [pubmed]
PHST- 1999/10/19 00:01 [medline]
PHST- 1999/10/19 00:00 [entrez]
AID - 10.1038/sj.mp.4000538 [doi]
PST - ppublish
SO  - Mol Psychiatry. 1999 Sep;4(5):437-42. doi: 10.1038/sj.mp.4000538.