PMID- 10526063
OWN - NLM
STAT- MEDLINE
DCOM- 20000425
LR  - 20191103
IS  - 0944-1166 (Print)
IS  - 0944-1166 (Linking)
VI  - 6
IP  - 3
DP  - 1999
TI  - Immediate increase of portal pressure, reflecting sinusoidal shear stress, 
      induced liver regeneration after partial hepatectomy.
PG  - 275-80
AB  - The mechanisms whereby hepatocytes in the normal liver can be primed for 
      replication following partial hepatectomy (PHx) are poorly understood. To 
      determine whether "shear stress," which is induced by acute portal hypertension 
      after PHx, is involved in liver regeneration, we studied liver regeneration in 
      rats with splenic transposition (SPT) in which we can minimize the postoperative 
      elevation of portal pressure. Rats underwent 70% PHx following splenic 
      transposition or sham surgery and were killed at various time points to measure 
      portal pressure and other factors. In the control groups, the portal pressure was 
      significantly increased immediately after surgery, peaking at 48 h, and returning 
      to near the preoperative levels by 168 h after PHx. In the SPT group, although 
      portal pressure increased immediately, it decreased to the control levels 6 h 
      after PHx and thereafter repeatedly increased. Tumor necrosis factor-alpha 
      (TNF-alpha) and interleukin-6 (IL-6) levels peaked at 24 and 6 h after PHx, 
      respectively. Proliferative cell analysis was done using MIB-5 antibody, and 
      there were no significant differences between the two groups. Furthermore, liver 
      weight was restored in the same way in both groups. Taken together, the results 
      suggest that an immediate increase in portal pressure is necessary for the 
      initiation of liver regeneration.
FAU - Niiya, T
AU  - Niiya T
AD  - Second Department of Surgery, School of Medicine, Showa University, 1-5-8 
      Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan.
FAU - Murakami, M
AU  - Murakami M
FAU - Aoki, T
AU  - Aoki T
FAU - Murai, N
AU  - Murai N
FAU - Shimizu, Y
AU  - Shimizu Y
FAU - Kusano, M
AU  - Kusano M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - J Hepatobiliary Pancreat Surg
JT  - Journal of hepato-biliary-pancreatic surgery
JID - 9431940
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - *Hepatectomy/methods
MH  - Hypertension, Portal/diagnosis/*physiopathology
MH  - Interleukin-6/*analysis
MH  - Liver/pathology
MH  - Liver Regeneration/*physiology
MH  - Male
MH  - Organ Size
MH  - Probability
MH  - Rats
MH  - Rats, Wistar
MH  - Reference Values
MH  - Spleen/surgery
MH  - Stress, Mechanical
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 1999/10/20 09:00
MHDA- 2000/04/29 09:00
CRDT- 1999/10/20 09:00
PHST- 1999/10/20 09:00 [pubmed]
PHST- 2000/04/29 09:00 [medline]
PHST- 1999/10/20 09:00 [entrez]
AID - 90060275.534 [pii]
AID - 10.1007/s005340050118 [doi]
PST - ppublish
SO  - J Hepatobiliary Pancreat Surg. 1999;6(3):275-80. doi: 10.1007/s005340050118.