PMID- 10526539
OWN - NLM
STAT- MEDLINE
DCOM- 19991102
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 114
IP  - 1
DP  - 1999 Oct 1
TI  - Fluorescence in situ hybridization analysis of complex translocations in two 
      newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia 
      patients.
PG  - 71-4
AB  - Two different complex translocations from newly diagnosed cases of Philadelphia 
      chromosome-positive chronic myelogenous leukemia (CML) were characterized by 
      G-banding and fluorescence in situ hybridization (FISH) analysis. In one case, a 
      unique balanced t(9;22;9;11) (q34;q11;p22;q23) was identified by G-banding, and 
      confirmed by FISH using MBCR/ABL and painting probes. In the second case, an 
      apparently balanced t(19;22) was identified by G-banding analysis. FISH using 
      MBCR/ABL probe detected the fusion gene on the derivative chromosome 22, 
      indicating the involvement of chromosome 9. Further FISH analysis with selected 
      painting probes showed that the t(19;22) was a result of a complex translocation 
      involving chromosomes 9, 19, 21, and 22.
FAU - Rajcan-Separovic, E
AU  - Rajcan-Separovic E
AD  - Department of Pathology, B. C. Children's Hospital, Vancouver, Canada.
FAU - Bence-Bruckler, I
AU  - Bence-Bruckler I
FAU - Wells, P
AU  - Wells P
FAU - Wang, H
AU  - Wang H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 19
MH  - *Chromosomes, Human, Pair 22
MH  - *Chromosomes, Human, Pair 9
MH  - Humans
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics
MH  - Male
MH  - *Translocation, Genetic
EDAT- 1999/10/20 00:00
MHDA- 1999/10/20 00:01
CRDT- 1999/10/20 00:00
PHST- 1999/10/20 00:00 [pubmed]
PHST- 1999/10/20 00:01 [medline]
PHST- 1999/10/20 00:00 [entrez]
AID - S0165460899000473 [pii]
AID - 10.1016/s0165-4608(99)00047-3 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Oct 1;114(1):71-4. doi: 
      10.1016/s0165-4608(99)00047-3.