PMID- 10529606
OWN - NLM
STAT- MEDLINE
DCOM- 19991109
LR  - 20220330
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 120 Suppl 1
DP  - 1999
TI  - Tumor necrosis factor-alpha mediates antiapoptotic signals partially via p38 MAP 
      kinase activation in human eosinophils.
PG  - 54-9
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine with many 
      biological effects on a variety of cells. In particular, TNF-alpha has been shown 
      to act as a death or survival factor which mediates apoptosis or antiapoptotic 
      signals in various types of cells. In eosinophils, TNF-alpha has been reported to 
      activate eosinophil functions. However, it is not clearly defined whether 
      TNF-alpha delivers antiapoptotic signals in eosinophils. In order to determine 
      whether TNF-alpha prevents eosinophil apoptosis, we examined the effect of 
      TNF-alpha on eosinophil apoptosis by the survival assay and cell cycle analysis. 
      We also determined whether intracellular MAP kinases (ERKs, Jun kinase/JNK, and 
      p38 MAP kinase) are involved in the TNF-alpha-induced signaling for the 
      prevention of eosinophil apoptosis. We showed that TNF-alpha mediated 
      antiapoptotic signals in human eosinophils in part via activation of p38 MAP 
      kinase, but not via activation of ERKs and JNK. Our data suggest that 
      TNF-alpha/p38 MAP kinase pathways are involved in the regulation of eosinophil 
      survival and, thus, would be important for the development of allergic 
      eosinophil-rich inflammation.
FAU - Tsukahara, K
AU  - Tsukahara K
AD  - Department of Internal Medicine II, Chiba University School of Medicine, Chiba, 
      Japan.
FAU - Nakao, A
AU  - Nakao A
FAU - Hiraguri, M
AU  - Hiraguri M
FAU - Miike, S
AU  - Miike S
FAU - Mamura, M
AU  - Mamura M
FAU - Saito, Y
AU  - Saito Y
FAU - Iwamoto, I
AU  - Iwamoto I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Apoptosis/*drug effects
MH  - Cells, Cultured
MH  - Eosinophils/metabolism/*pathology
MH  - Humans
MH  - Mitogen-Activated Protein Kinases/*metabolism
MH  - Recombinant Proteins/pharmacology
MH  - Signal Transduction/drug effects
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - p38 Mitogen-Activated Protein Kinases
EDAT- 1999/10/26 00:00
MHDA- 1999/10/26 00:01
CRDT- 1999/10/26 00:00
PHST- 1999/10/26 00:00 [pubmed]
PHST- 1999/10/26 00:01 [medline]
PHST- 1999/10/26 00:00 [entrez]
AID - 53596 [pii]
AID - 10.1159/000053596 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 1999;120 Suppl 1:54-9. doi: 10.1159/000053596.