PMID- 10531691
OWN - NLM
STAT- MEDLINE
DCOM- 19991229
LR  - 20190516
IS  - 0066-782X (Print)
IS  - 0066-782X (Linking)
VI  - 72
IP  - 4
DP  - 1999 Apr
TI  - Aortic stenosis. Gender influence on left ventricular geometry and function in 
      patients under 70 years of age.
PG  - 475-82
AB  - OBJECTIVE: To verify if adaptive left ventricle (LV) characteristics are also 
      present in individuals under 70 years of age with severe aortic stenosis (AS). 
      METHODS: The study comprised 40 consecutive patients under 70 years of age with 
      AS and no associated coronary artery disease, referred for valve surgery. Out of 
      the 40 patients, 22 were men and 18 women, and the mean age was 49.8 +/- 14.3 
      years. Cardiac symptoms, presence of systemic hypertension (SH), functional class 
      according to the New York Heart Association (NYHA), and valve lesion etiology 
      were considered. LV cavity dimensions, ejection fraction (EF), fractional 
      shortening (FS), mass (MS), and relative diastolic thickness (RDT) were examined 
      by Doppler echocardiography. RESULTS: Fourteen (63.6%) men and 11 (61.6%) women 
      were classified as NYHA class III/IV (p = 0.70). There was no difference in the 
      frequency of angina, syncope or dyspnea between genders. The incidence of SH was 
      greater in women than in men (10 versus 2, p = 0.0044). Women had a smaller LV 
      end-diastolic diameter index (32.1 +/- 6.5 x 36.5 +/- 5.3 mm/m2, p = 0.027), LV 
      end-systolic diameter index (19.9 +/- 5.9 x 26.5 +/- 6.4 mm/m2, p = 0.0022) and 
      LV mass index (MS) (211.4 +/- 71.1 x 270.9 +/- 74.9 g/m2, p = 0.017) when 
      compared with men. EF (66.2 +/- 13.4 x 52.0 +/- 14.6%, p = 0.0032), FS (37.6 +/- 
      10.7 x 27.9 +/- 9.6%, p = 0.0046) and RDT (0.58 +/- 0.22 x 0.44 +/- 0.09, p = 
      0.0095) were significantly greater in women than in men. CONCLUSION: It is the 
      patient gender rather than age that influences left ventricular adaptive response 
      to AS.
FAU - da Rocha, A S
AU  - da Rocha AS
AD  - Hospital de Cardiologia de Laranjeiras, Ministerio da Saude-Rio de Janeiro, 
      Brazil.
FAU - Pereira, M A
AU  - Pereira MA
FAU - Rocha, N de N
AU  - Rocha Nde N
FAU - Soares, R de C
AU  - Soares Rde C
FAU - Garcia, C
AU  - Garcia C
FAU - Grandelle, R
AU  - Grandelle R
FAU - da Silva, P R
AU  - da Silva PR
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Arq Bras Cardiol
JT  - Arquivos brasileiros de cardiologia
JID - 0421031
SB  - IM
MH  - Adult
MH  - Aortic Valve Stenosis/*physiopathology
MH  - Female
MH  - Heart Ventricles/anatomy & histology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sex Factors
MH  - Ventricular Function, Left/*physiology
EDAT- 1999/10/26 00:00
MHDA- 1999/10/26 00:01
CRDT- 1999/10/26 00:00
PHST- 1999/10/26 00:00 [pubmed]
PHST- 1999/10/26 00:01 [medline]
PHST- 1999/10/26 00:00 [entrez]
AID - 10.1590/s0066-782x1999000400007 [doi]
PST - ppublish
SO  - Arq Bras Cardiol. 1999 Apr;72(4):475-82. doi: 10.1590/s0066-782x1999000400007.