PMID- 10537025
OWN - NLM
STAT- MEDLINE
DCOM- 19991229
LR  - 20190910
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 20
IP  - 2
DP  - 1999 Mar-Apr
TI  - Controlling caloric consumption: protocols for rodents and rhesus monkeys.
PG  - 157-65
AB  - One approach for investigating biological aging is to compare control-fed animals 
      with others restricted in calorie intake by 20% or more. Caloric restriction (CR) 
      is the only intervention shown to extend the maximum lifespan of several 
      invertebrates and vertebrates including spiders, fish, rats and mice. The 
      capacity of CR to retard aging in nonhuman primates is now being explored. The 
      rodent studies show that CR opposes the development of many age-associated 
      pathophysiological changes, including changes to the brain and changes in 
      learning and behavior. One goal of studying CR in rodent is to determine the 
      mechanisms by which it retards aging to design interventions that duplicate those 
      effects. The methods that we use for conducting CR studies on mice and rhesus 
      monkeys are described. We employ procedures designed to achieve a high degree of 
      caloric control for all animals in the study. As used in our studies, this 
      control includes the following features: 1) animals are individually housed, and 
      2) all individuals in the control group eat the same number of calories (i.e., 
      they are not fed ad lib). Although this method results in strict caloric control 
      for all animals, there seems to be considerable procedural flexibility for the 
      successful conduct of CR studies.
FAU - Pugh, T D
AU  - Pugh TD
AD  - Institute on Aging, University of Wisconsin, Madison 53706, USA.
FAU - Klopp, R G
AU  - Klopp RG
FAU - Weindruch, R
AU  - Weindruch R
LA  - eng
GR  - K01 AG00650/AG/NIA NIH HHS/United States
GR  - P01 AG11915/AG/NIA NIH HHS/United States
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
SB  - IM
MH  - Aging/physiology
MH  - Animal Feed/standards
MH  - Animals
MH  - Diet, Reducing/history/*methods/standards
MH  - Energy Intake/*physiology
MH  - Female
MH  - Food Deprivation/physiology
MH  - History, 20th Century
MH  - Macaca mulatta
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Rats
RF  - 48
EDAT- 1999/10/28 00:00
MHDA- 1999/10/28 00:01
CRDT- 1999/10/28 00:00
PHST- 1999/10/28 00:00 [pubmed]
PHST- 1999/10/28 00:01 [medline]
PHST- 1999/10/28 00:00 [entrez]
AID - S0197458099000433 [pii]
AID - 10.1016/s0197-4580(99)00043-3 [doi]
PST - ppublish
SO  - Neurobiol Aging. 1999 Mar-Apr;20(2):157-65. doi: 10.1016/s0197-4580(99)00043-3.