PMID- 10539786
OWN - NLM
STAT- MEDLINE
DCOM- 19991124
LR  - 20180330
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 129
IP  - 11
DP  - 1999 Nov
TI  - Folic acid supplementation of pregnant mice suppresses heat-induced neural tube 
      defects in the offspring.
PG  - 2070-3
AB  - Neural tube defects (NTD) are a group of malformations that result from the 
      failure of the neural tube to close early in embryonic development and among the 
      most common congenital malformations in humans. It has been reported that a 
      substantial proportion of NTD in humans can be prevented by folic acid (FA) 
      supplementation prior to conception and during the first months of pregnancy, and 
      myo-inositol (MI) was shown to reduce the incidence of NTD in curly tail mice 
      which are not prevented by FA. Brief maternal hyperthermia (HT) early in 
      pregnancy has been implicated in NTD both in humans and laboratory animals, and 
      anterior NTD including exencephaly and anencephaly are induced frequently when 
      pregnant mice are exposed to HT. We examined the effect of FA or MI 
      supplementation of pregnant mice on the occurrence of heat-induced NTD in the 
      offspring. When pregnant mice were treated with FA (3 mg/kg) daily from 
      gestational day (GD) 0.5 through GD 9.5 and heated at GD 8.5, the prevalence of 
      NTD in the fetuses (26.6%) was significantly lower than the corresponding figure 
      in the HT alone group (38.6%; P < 0.05). However we failed to detect the 
      preventive effect of MI (500 mg/kg). The results of this study suggest that 
      prenatal FA supplementation decreases HT-induced NTD in mice and sufficient FA 
      intake during early pregnancy may be recommended to avoid the birth of malformed 
      children.
FAU - Shin, J H
AU  - Shin JH
AD  - Department of Anatomy and Developmental Biology and Congenital Anomaly Research 
      Center, Faculty of Medicine, Kyoto University, Kyoto 606-8501, Japan.
FAU - Shiota, K
AU  - Shiota K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Hematinics)
RN  - 4L6452S749 (Inositol)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Diet
MH  - Embryonic and Fetal Development/drug effects
MH  - Female
MH  - Folic Acid/administration & dosage/*therapeutic use
MH  - Hematinics/administration & dosage/*therapeutic use
MH  - Hyperthermia, Induced/*adverse effects
MH  - Inositol/therapeutic use
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neural Tube Defects/etiology/*prevention & control
MH  - Pregnancy
EDAT- 1999/10/28 00:00
MHDA- 1999/10/28 00:01
CRDT- 1999/10/28 00:00
PHST- 1999/10/28 00:00 [pubmed]
PHST- 1999/10/28 00:01 [medline]
PHST- 1999/10/28 00:00 [entrez]
AID - 10.1093/jn/129.11.2070 [doi]
PST - ppublish
SO  - J Nutr. 1999 Nov;129(11):2070-3. doi: 10.1093/jn/129.11.2070.