PMID- 10540875
OWN - NLM
STAT- MEDLINE
DCOM- 19991126
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 57
IP  - 10
DP  - 1999 Oct
TI  - [Gene structure and transcriptional regulation of vitamin A, D binding proteins 
      and nuclear receptors].
PG  - 2284-94
AB  - Vitamin A and D play an important role in many biological processes including 
      cell differentiation, proliferation and bone metabolism. These effects are 
      believed to be mediated by specific nuclear receptors such as retinoic acid 
      receptors (RARs) or vitamin D receptor (VDR), that regulate the transcription of 
      a particular set of target genes. Hetero-dimers of RAR or VDR to retinoid X 
      receptors (RXRs) bind target enhancer elements in their gene promoters. The 
      target enhancer elements are referred as RA response elements (RAREs) or vitamin 
      D response elements (VDREs), and composed of two hexamer core motife. DNA-bound 
      RAR/VDR control transcription in a ligand-binding dependent way in co-operation 
      with a multiprotein complex containing RNA polymerase II and a series of 
      auxiliary factors, TFIIA, B, D, E, F and H. During process of ligand-induced 
      transactivation by nuclear receptors, nuclear coactivators interacting with the 
      AF-2 including ligand binding domain (LBD) seems to be involved. Several 
      transcriptional coactivators and corepressors have been recently identified, and 
      their function is currently under investigation.
FAU - Takeyama, K
AU  - Takeyama K
AD  - Institute of Molecular and Cellular Biosciences, University of Tokyo.
FAU - Kato, S
AU  - Kato S
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 11103-57-4 (Vitamin A)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Genes, Regulator/*physiology
MH  - Humans
MH  - Receptors, Calcitriol/*genetics/*physiology
MH  - Receptors, Retinoic Acid/*genetics/*physiology
MH  - Vitamin A/metabolism
MH  - Vitamin D/metabolism
RF  - 35
EDAT- 1999/12/14 00:00
MHDA- 1999/12/14 00:01
CRDT- 1999/12/14 00:00
PHST- 1999/12/14 00:00 [pubmed]
PHST- 1999/12/14 00:01 [medline]
PHST- 1999/12/14 00:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 1999 Oct;57(10):2284-94.