PMID- 10541046
OWN - NLM
STAT- MEDLINE
DCOM- 19991105
LR  - 20190826
IS  - 0165-2478 (Print)
IS  - 0165-2478 (Linking)
VI  - 70
IP  - 1
DP  - 1999 Oct 1
TI  - Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 
      production is inhibited by taurine chloramine in rat C6 glioma cells.
PG  - 9-14
AB  - Taurine monochloramine (Tau-Cl) is formed through the actions of a 
      halide-dependent myeloperoxidase system associated with polymorphonuclear 
      leukocytes (PMN). Tau-Cl inhibits production of inflammatory mediators by 
      activated macrophages, and PMN. Recently, Tau-Cl was shown to inhibit production 
      of nitric oxide and prostaglandin E2 by activated C6 glioma cells. Since 
      chemokines, secreted by activated glial cells, play a prominent role in eliciting 
      inflammatory responses in the central nervous system, the effects of Tau-Cl on 
      production of monocyte chemoattractant protein-1 (MCP-1) and macrophage 
      inflammatory protein-2 (MIP-2) were determined in activated C6 glioma cells. 
      Tau-Cl inhibited production of MCP-1 and MIP-2 in a concentration-dependent 
      manner, and was most potent against MCP-1. Tau-Cl exerted a transient inhibition 
      of the temporal expression of MCP-1 and MIP-2 mRNAs during the first 4 h of 
      activation. Although both chemokine mRNA levels were similar to those of control 
      cells after 8-24 h of activation, production of the chemokine proteins, 
      especially MCP-1, remained markedly low. These results suggest that Tau-Cl 
      inhibits production of MCP-1 and MIP-2 in activated C6 cells primarily through 
      post-transcriptional mechanisms.
FAU - Liu, Y
AU  - Liu Y
AD  - Department of Developmental Biochemistry, New York State Institute for Basic 
      Research in Developmental Disabilities, Staten Island 10314-6330, USA.
FAU - Schuller-Levis, G
AU  - Schuller-Levis G
FAU - Quinn, M R
AU  - Quinn MR
LA  - eng
GR  - HL-49942/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CXCL2)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Monokines)
RN  - 0 (RNA, Messenger)
RN  - 1EQV5MLY3D (Taurine)
RN  - 51036-13-6 (N-chlorotaurine)
SB  - IM
MH  - Animals
MH  - Chemokine CCL4
MH  - Chemokine CXCL2
MH  - Glioma
MH  - Inflammation Mediators/*pharmacology
MH  - Macrophage Inflammatory Proteins/*biosynthesis
MH  - Monokines/*biosynthesis
MH  - Neuroglia/*drug effects/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Taurine/*analogs & derivatives/pharmacology
MH  - Tumor Cells, Cultured
EDAT- 1999/11/30 00:00
MHDA- 1999/11/30 00:01
CRDT- 1999/11/30 00:00
PHST- 1999/11/30 00:00 [pubmed]
PHST- 1999/11/30 00:01 [medline]
PHST- 1999/11/30 00:00 [entrez]
AID - S0165-2478(99)00119-4 [pii]
AID - 10.1016/s0165-2478(99)00119-4 [doi]
PST - ppublish
SO  - Immunol Lett. 1999 Oct 1;70(1):9-14. doi: 10.1016/s0165-2478(99)00119-4.