PMID- 10541749
OWN - NLM
STAT- MEDLINE
DCOM- 19991123
LR  - 20190721
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 128
IP  - 4
DP  - 1999 Oct
TI  - Mechanism of the silent period following transcranial magnetic stimulation. 
      Evidence from epidural recordings.
PG  - 539-42
AB  - We investigated the nature of the silent period (SP) following transcranial 
      magnetic stimulation by recording corticospinal volleys in a patient with 
      implanted cervical epidural electrodes. Single suprathreshold test stimuli and 
      paired stimuli at interstimulus intervals (ISIs) of 50-200 ms were delivered 
      while the subject maintained a constant background contraction. The silent period 
      duration from a single test stimulus was 357+/-62 ms. The test motor-evoked 
      potentials were markedly reduced at all the ISIs tested. The I (indirect) waves 
      induced by the test stimulus were largely unchanged at an ISI of 50 ms, 
      suggesting that there was little change in motor cortex excitability. However, 
      the corticospinal volleys, especially the late I waves, were substantially 
      reduced at ISIs of 100 ms, 150 ms, and 200 ms. Our findings suggest that the 
      early part of the SP is mainly due to spinal mechanisms, while the late part of 
      the SP is related to reduced motor cortex excitability.
FAU - Chen, R
AU  - Chen R
AD  - Division of Neurology and Playfair Neuroscience Unit, Toronto Western Hospital, 
      University Health Network, University of Toronto, Ontario, Canada. 
      t49mdns@torhosp.toronto.on.ca
FAU - Lozano, A M
AU  - Lozano AM
FAU - Ashby, P
AU  - Ashby P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
SB  - IM
MH  - Accidents, Traffic
MH  - Adult
MH  - Brachial Plexus/*injuries
MH  - Cerebral Cortex/*physiopathology
MH  - Electric Stimulation
MH  - Electromyography
MH  - Humans
MH  - Male
MH  - Motor Cortex/physiopathology
MH  - Muscle, Skeletal/*innervation/physiopathology
MH  - Neural Pathways/physiopathology
MH  - Spinal Cord/*physiopathology
MH  - *Transcranial Magnetic Stimulation
EDAT- 1999/10/29 00:00
MHDA- 1999/10/29 00:01
CRDT- 1999/10/29 00:00
PHST- 1999/10/29 00:00 [pubmed]
PHST- 1999/10/29 00:01 [medline]
PHST- 1999/10/29 00:00 [entrez]
AID - 91280539.221 [pii]
AID - 10.1007/s002210050878 [doi]
PST - ppublish
SO  - Exp Brain Res. 1999 Oct;128(4):539-42. doi: 10.1007/s002210050878.