PMID- 10543763
OWN - NLM
STAT- MEDLINE
DCOM- 20000127
LR  - 20240314
IS  - 0066-4804 (Print)
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Linking)
VI  - 43
IP  - 11
DP  - 1999 Nov
TI  - Distribution of insertion sequence-like element IS1272 and its position relative 
      to methicillin resistance genes in clinically important Staphylococci.
PG  - 2780-2
AB  - The distribution of insertion sequence-like element IS1272 was analyzed for 
      clinical isolates of Staphylococcus aureus, Staphylococcus epidermidis, and 
      Staphylococcus haemolyticus. In each of the staphylococcal species, IS1272 was 
      detected in both methicillin-resistant (MR) and methicillin-susceptible strains 
      of different genetic types. In MR isolates, IS1272 was generally located 
      downstream of the truncated mecR1 gene (DeltamecR1), with an identical junction 
      sequence occurring between DeltamecR1 and IS1272, although insertion of an 
      additional gene sequence in the junction sequence was detected in one S. 
      epidermidis isolate. These findings suggest that the mec element with the 
      rearranged form of mecR1 (DeltamecR1-IS1272) has been transmitted to multiple 
      clones of staphylococci.
FAU - Kobayashi, N
AU  - Kobayashi N
AD  - Department of Hygiene, Sapporo Medical University School of Medicine, Chuo-ku, 
      Sapporo 060-8556, Japan. nkobayas@sapmed.ac.jp
FAU - Urasawa, S
AU  - Urasawa S
FAU - Uehara, N
AU  - Uehara N
FAU - Watanabe, N
AU  - Watanabe N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 0 (Bacterial Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA Transposable Elements)
RN  - 0 (DNA, Bacterial)
RN  - 0 (MecI protein, Staphylococcus)
RN  - 0 (Penicillin-Binding Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (mecR1 protein, Staphylococcus aureus)
RN  - EC 2.3.2.12 (Peptidyl Transferases)
RN  - EC 2.4.1.- (Hexosyltransferases)
RN  - EC 3.4.17.8 (Muramoylpentapeptide Carboxypeptidase)
SB  - IM
MH  - Bacterial Proteins/genetics
MH  - Base Sequence
MH  - Carrier Proteins/*genetics
MH  - DNA Transposable Elements/*genetics
MH  - DNA, Bacterial/*genetics
MH  - Genes, Bacterial/*genetics
MH  - *Hexosyltransferases
MH  - Humans
MH  - Methicillin Resistance/*genetics
MH  - Molecular Sequence Data
MH  - Muramoylpentapeptide Carboxypeptidase/*genetics
MH  - Penicillin-Binding Proteins
MH  - *Peptidyl Transferases
MH  - Polymerase Chain Reaction
MH  - Repressor Proteins/genetics
MH  - Staphylococcal Infections/microbiology
MH  - Staphylococcus/*drug effects/*genetics
PMC - PMC89559
EDAT- 1999/10/30 00:00
MHDA- 1999/10/30 00:01
PMCR- 1999/11/01
CRDT- 1999/10/30 00:00
PHST- 1999/10/30 00:00 [pubmed]
PHST- 1999/10/30 00:01 [medline]
PHST- 1999/10/30 00:00 [entrez]
PHST- 1999/11/01 00:00 [pmc-release]
AID - 0378 [pii]
AID - 10.1128/AAC.43.11.2780 [doi]
PST - ppublish
SO  - Antimicrob Agents Chemother. 1999 Nov;43(11):2780-2. doi: 10.1128/AAC.43.11.2780.