PMID- 10544157
OWN - NLM
STAT- MEDLINE
DCOM- 20000104
LR  - 20181113
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 107
IP  - 11
DP  - 1999 Nov
TI  - Cord serum immunoglobulin E related to the environmental contamination of human 
      placentas with organochlorine compounds.
PG  - 895-9
AB  - Allergic diseases are on the rise in both prevalence and severity, especially in 
      industrialized countries. The process of allergic sensitization needs an 
      understanding of the role environmental factors play in its development. In 
      addition to traditionally considered air pollutants, various persistent 
      organochlorine pollutants, which accumulate in the human body over a lifetime via 
      food intake, are toxic in humans. Placental contamination by chemicals may act as 
      a biologic marker for the exposure of the mother or for the fetus via 
      transplacental transfer. Placentas were collected from term deliveries in two 
      Slovak regions. The samples were then analyzed for 21 selected organochlorine 
      compounds. Specimens of cord blood from 2,050 neonates were gathered for the 
      determination of levels of total immunoglobulin E (IgE). The regions were chosen 
      according to their environmental characteristics: a city polluted with organic 
      chemical industry versus a rural region devoid of industrial sources of 
      pollution. In addition, data regarding the incidence rate of atopic eczema cases 
      in the regions were considered. Comparisons between regions revealed that both 
      the placental contamination with 16 of 21 organochlorine compounds and the cord 
      serum IgE levels were significantly higher in the industrial region. The findings 
      pointed to an association between organochlorine compounds and the higher levels 
      of total IgE in newborns, signaling a higher allergic sensitization in the 
      industrial region. This association was supported by the higher incidence rate of 
      atopic eczema cases in the population registered in the industrial region.
FAU - Reichrtova, E
AU  - Reichrtova E
AD  - Institute of Preventive and Clinical Medicine, Bratislava, Slovakia. 
      reichrt@upkm.sk
FAU - Ciznar, P
AU  - Ciznar P
FAU - Prachar, V
AU  - Prachar V
FAU - Palkovicova, L
AU  - Palkovicova L
FAU - Veningerova, M
AU  - Veningerova M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Biomarkers/analysis
MH  - Eczema/etiology
MH  - Environmental Exposure
MH  - Environmental Pollutants/adverse effects/*immunology
MH  - Female
MH  - Fetal Blood/*immunology
MH  - Humans
MH  - Hypersensitivity/*etiology
MH  - Immunoglobulin E/*blood
MH  - Industry
MH  - Infant, Newborn
MH  - Male
MH  - Placenta/chemistry
MH  - Polychlorinated Biphenyls/adverse effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
PMC - PMC1566702
EDAT- 1999/11/02 00:00
MHDA- 1999/11/02 00:01
PMCR- 1999/11/01
CRDT- 1999/11/02 00:00
PHST- 1999/11/02 00:00 [pubmed]
PHST- 1999/11/02 00:01 [medline]
PHST- 1999/11/02 00:00 [entrez]
PHST- 1999/11/01 00:00 [pmc-release]
AID - sc271_5_1835 [pii]
AID - 10.1289/ehp.107-1566702 [doi]
PST - ppublish
SO  - Environ Health Perspect. 1999 Nov;107(11):895-9. doi: 10.1289/ehp.107-1566702.