PMID- 10547158
OWN - NLM
STAT- MEDLINE
DCOM- 19991208
LR  - 20061115
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 19
IP  - 10
DP  - 1999 Oct
TI  - Increase in circulating levels of monocyte chemoattractant protein-1 with aging.
PG  - 1179-82
AB  - Monocyte chemoattractant protein-1 (MCP-1) is a member of chemokines with 
      chemoattractant activity for monocytes, T cells, mast cells, and basophils. 
      Precursor mRNA or protein was detected at high levels in the lesions of several 
      diseases, such as pulmonary fibrosis, rheumatoid arthritis, atherosclerosis, and 
      some types of tumors. The regulation of MCP-1 production and the role of this 
      chemokine in pathophysiologic states, however, remain largely unknown. In this 
      study, using an enzyme-linked immunosorbent assay (ELISA), we measured the 
      circulating MCP-1 levels in 405 healthy Japanese subjects of various ages, 
      eliciting a profound age-dependent MCP-1 increase. Multivariate regression 
      analysis revealed that significant predictors of MCP-1 value for males were age 
      (p = 0.033) and serum triglyceride (p = 0.039). For females, age was also a 
      significant predictor (p = 0.00002). One possible explanation is that the plasma 
      MCP-1 concentration might reflect the existence of atherosclerosis, although the 
      plasma MCP-1 concentration from patients with coronary artery disease or 
      cerebrovascular accidents appears not to differ from age-matched, disease-free 
      controls. This is the first report linking an increase in a particular chemokine 
      level with aging.
FAU - Inadera, H
AU  - Inadera H
AD  - Department of Molecular Preventive Medicine and CREST, School of Medicine, 
      University of Tokyo, Japan.
FAU - Egashira, K
AU  - Egashira K
FAU - Takemoto, M
AU  - Takemoto M
FAU - Ouchi, Y
AU  - Ouchi Y
FAU - Matsushima, K
AU  - Matsushima K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*blood
MH  - Chemokine CCL2/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - 10.1089/107999099313127 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 1999 Oct;19(10):1179-82. doi: 10.1089/107999099313127.