PMID- 10548280
OWN - NLM
STAT- MEDLINE
DCOM- 19991213
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 64
IP  - 3
DP  - 1999 Nov
TI  - Peptide immunoreactivity in aged rat cortex and hippocampus as a function of 
      memory and BDNF infusion.
PG  - 625-35
AB  - Brain-derived neurotrophic factor (BDNF) modulates neuropeptide levels in 
      hippocampus and cortex of young adult rats. Neuropeptide levels are altered in 
      some age-related disorders, such as Alzheimer's and Parkinson's Disease. BDNF may 
      be able to rectify peptide abnormalities but, because plasticity decreases with 
      age, BDNF may not alter peptide levels as readily in aged animals. To determine 
      if BDNF would regulate peptide levels in aged rats, young, aged memory-impaired, 
      and unimpaired rats were infused with BDNF or vehicle into hippocampus and 
      cortex. Cell profile counts, cell profile areas, fiber counts, and/or fiber 
      terminal densities were measured for sections immunostained for neuropeptide Y 
      (NPY), somatostatin (SOM), cholecystokinin-8 (CCK), and dynorphin A(1-8) (DYN). 
      Results showed that BDNF upregulated cortical NPY-immunoreactivity (ir) and 
      SOM-ir, upregulated hippocampal NPY-ir, and downregulated hippocampal DYN-ir in 
      both aged and young rats. In addition, BDNF significantly and selectively 
      normalized the areas of atrophied deep cortical CCK-ir cell profiles in 
      aged-impaired rats. Finally, decreased CCK-ir fiber density was found in the 
      hippocampal formation of aged memory-impaired rats.
FAU - Croll, S D
AU  - Croll SD
AD  - Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
FAU - Chesnutt, C R
AU  - Chesnutt CR
FAU - Greene, N A
AU  - Greene NA
FAU - Lindsay, R M
AU  - Lindsay RM
FAU - Wiegand, S J
AU  - Wiegand SJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Neuropeptides)
RN  - 51110-01-1 (Somatostatin)
RN  - 74913-18-1 (Dynorphins)
RN  - 9011-97-6 (Cholecystokinin)
SB  - IM
MH  - Aging/*metabolism/*psychology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/administration & dosage/*pharmacology
MH  - Cell Count
MH  - Cerebral Cortex/drug effects/growth & development/*metabolism
MH  - Cholecystokinin/metabolism
MH  - Dynorphins/metabolism
MH  - Hippocampus/drug effects/growth & development/*metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Maze Learning/physiology
MH  - Memory/drug effects/*physiology
MH  - Nerve Fibers/metabolism
MH  - Neurons/metabolism
MH  - Neuropeptide Y/metabolism
MH  - Neuropeptides/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Somatostatin/metabolism
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - S0091-3057(99)00122-7 [pii]
AID - 10.1016/s0091-3057(99)00122-7 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1999 Nov;64(3):625-35. doi: 
      10.1016/s0091-3057(99)00122-7.