PMID- 10548411
OWN - NLM
STAT- MEDLINE
DCOM- 19991206
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 274
IP  - 3
DP  - 1999 Oct 29
TI  - Long-term effects of a single dose of brain-derived neurotrophic factor on 
      motoneuron survival following spinal root avulsion in the adult rat.
PG  - 147-50
AB  - The long-term effect of a single dose of Brain-derived neurotrophic factor (BDNF) 
      treatment on adult motoneuron survival and on expression of nitric oxide synthase 
      (NOS) following nerve injury (avulsion) was investigated and compared with that 
      of continuous BDNF treatment. By 6 weeks post-injury, more than 80% of 
      motoneurons survived in animals treated with either a single dose or continuous 
      treatment of BDNF, while only 30% of motoneurons survived in control animals 
      (avulsion only). There were no significant differences in motoneuron survival 
      between animals receiving a single dose and those with continuous treatment of 
      BDNF. Additionally, the expression of NOS in avulsed motoneurons was almost 
      completely inhibited in all BDNF treatment groups regardless of the mode of 
      administration (single vs. continuous). These data indicate that treatment with a 
      single dose of BDNF at the time of injury can inhibit NOS expression and provide 
      the first evidence that in this situation BDNF has a long-term rescue effect on 
      adult motoneuron survival after root avulsion.
FAU - Chai, H
AU  - Chai H
AD  - Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong 
      Kong.
FAU - Wu, W
AU  - Wu W
FAU - So, K F
AU  - So KF
FAU - Prevette, D M
AU  - Prevette DM
FAU - Oppenheim, R W
AU  - Oppenheim RW
LA  - eng
GR  - NS 20402/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Coloring Agents)
RN  - 261QK3SSBH (Neutral Red)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cell Count
MH  - Cell Survival/drug effects
MH  - Coloring Agents
MH  - Male
MH  - Motor Neurons/*cytology/drug effects/enzymology
MH  - Neutral Red
MH  - Nitric Oxide Synthase/analysis/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Nerve Roots/*cytology/*injuries
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - S0304394099006710 [pii]
AID - 10.1016/s0304-3940(99)00671-0 [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 Oct 29;274(3):147-50. doi: 10.1016/s0304-3940(99)00671-0.