PMID- 10549099
OWN - NLM
STAT- MEDLINE
DCOM- 19991214
LR  - 20201208
IS  - 0044-2771 (Print)
IS  - 0044-2771 (Linking)
VI  - 37
IP  - 10
DP  - 1999 Oct
TI  - [Changes in Helicobacter pylori gastritis caused by therapy with inhibitors of 
      gastric acid secretion].
PG  - 1029-36
AB  - In patients with Helicobacter pylori (Hp) gastritis long-term treatment with 
      omeprazole leads to a worsening of the corpus gastritis. In the present overview 
      we have analyzed the literature and our own studies to determine whether this 
      also applies to other proton pump inhibitors (PPI), H2-receptor antagonists 
      (H2-RA) and antacids. RESULTS: Every antisecretory therapy--vagotomy, antacids, 
      H2-RA and PPI--in patients with Hp gastritis leads to a worsening of the 
      following parameters: Grade of gastritis, activity of gastritis, grade of 
      replacement of foveolar epithelium by regenerative epithelium and grade of mucus 
      depletion. The incidence of intestinal metaplasia does not increase. Atrophic 
      gastritis has not been observed after one year of treatment; after five years of 
      treatment with PPI, development of atrophy is uncertain. In the antrum treatment 
      with PPI, but not with antacids or H2-RA, leads to an improvement in the 
      gastritis parameters. The question whether the aggravation of corpus gastritis 
      under antisecretory treatment might be detrimental over the long-term, whether, 
      for example, the more pronounced gastritis might increase the risk of a 
      subsequent carcinoma, remains to be clarified by long-term studies.
FAU - Stolte, M
AU  - Stolte M
AD  - Institut fur Pathologie, Klinikum Bayreuth.
FAU - Meining, A
AU  - Meining A
LA  - ger
PT  - Journal Article
PT  - Review
TT  - Veranderungen der Helicobacter-pylori-Gastritis durch sauresekretionshemmende 
      Therapie.
PL  - Germany
TA  - Z Gastroenterol
JT  - Zeitschrift fur Gastroenterologie
JID - 0033370
RN  - 0 (Antacids)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Antacids/*adverse effects/therapeutic use
MH  - Anti-Ulcer Agents/*adverse effects/therapeutic use
MH  - Gastric Mucosa/drug effects/pathology
MH  - Gastritis/chemically induced/*drug therapy/pathology
MH  - Helicobacter Infections/*drug therapy/pathology
MH  - *Helicobacter pylori/drug effects
MH  - Histamine H2 Antagonists/*adverse effects/therapeutic use
MH  - Humans
MH  - Long-Term Care
MH  - *Proton Pump Inhibitors
RF  - 32
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
PST - ppublish
SO  - Z Gastroenterol. 1999 Oct;37(10):1029-36.