PMID- 10549263
OWN - NLM
STAT- MEDLINE
DCOM- 19991117
LR  - 20231213
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 114
IP  - 2
DP  - 1999 Oct 15
TI  - A new translocation, t(2;4;12)(p21;q12;p13), in CD7-positive acute myeloid 
      leukemia: a variant form of t(4;12).
PG  - 96-9
AB  - We describe a 41-year-old man with CD7-positive acute myeloid leukemia (AML-M0) 
      with trilineage-myelodysplasia. Chromosome analysis of the bone marrow cells 
      showed 46.XY.t(2;4;12) (p21;q12;p13). Cytological and clinical features of our 
      case were quite similar to those of AML with t(4;12)(q11-12;p13). The karyotypic 
      interpretation was confirmed by fluorescence in situ hybridization (FISH) by 
      using the whole-chromosome painting probes specific for chromosomes 2, 4, and 12. 
      FISH analysis with the use of the YAC 936e2 probe, which covers the TEL gene, did 
      not show the split signal, suggesting that a gene other than TEL was involved in 
      the leukemogenesis of the present case. Our case with AML with 
      t(2;4;12)(p21;q12;p13) appears to be the first case of a variant type of AML with 
      t(4;12) (q11-12;p13).
FAU - Hamaguchi, H
AU  - Hamaguchi H
AD  - Department of Hematology, Musashino Red Cross Hospital, Tokyo, Japan.
FAU - Nagata, K
AU  - Nagata K
FAU - Yamamoto, K
AU  - Yamamoto K
FAU - Kobayashi, M
AU  - Kobayashi M
FAU - Takashima, T
AU  - Takashima T
FAU - Taniwaki, M
AU  - Taniwaki M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Antigens, CD7)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Proto-Oncogene Proteins c-ets)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Antigens, CD7/*analysis
MH  - Chromosomes, Human, Pair 12/genetics
MH  - Chromosomes, Human, Pair 2/genetics
MH  - Chromosomes, Human, Pair 4/genetics
MH  - DNA-Binding Proteins/genetics
MH  - Genetic Variation/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid/*genetics/*immunology/pathology
MH  - Male
MH  - Proto-Oncogene Proteins c-ets
MH  - *Repressor Proteins
MH  - Transcription Factors/genetics
MH  - Translocation, Genetic/*genetics
MH  - ETS Translocation Variant 6 Protein
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - S0165460899000606 [pii]
AID - 10.1016/s0165-4608(99)00060-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Oct 15;114(2):96-9. doi: 
      10.1016/s0165-4608(99)00060-6.