PMID- 10549273
OWN - NLM
STAT- MEDLINE
DCOM- 19991117
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 114
IP  - 2
DP  - 1999 Oct 15
TI  - Novel Philadelphia variant t(Y;9;22)(q12;q34;q11) in a case of chronic myeloid 
      leukemia.
PG  - 150-3
AB  - A novel Philadelphia (Ph) variant translocation, t(Y;9;22)(q12;q34;q11), was 
      detected in a 63-year-old man with a newly diagnosed chronic myeloid leukemia 
      (CML). Reverse transcription polymerase chain reaction (RT-PCR) analysis revealed 
      a b3a2 fusion transcript. Fluorescence in situ hybridization (FISH) utilizing 
      library probes, subtelomeric cosmid probes, and probes hybridizing to the ABL and 
      BCR genes showed a reciprocal three-way translocation involving Yq12, 9q34, and 
      22q11, and a BCR-ABL fusion signal on der(22). The subtelomeric Yq probe 
      hybridizing centromerically to the IL9 receptor gene and covering the centromeric 
      portion of the SYBL1 gene was found to be translocated to der(9).
FAU - Dierlamm, J
AU  - Dierlamm J
AD  - Department of Oncology and Haematology, University Hospital Eppendorf, Hamburg, 
      Germany.
FAU - Michaux, L
AU  - Michaux L
FAU - Stefanova, M
AU  - Stefanova M
FAU - Eggert, J
AU  - Eggert J
FAU - Leberecht, P
AU  - Leberecht P
FAU - Seeger, D
AU  - Seeger D
FAU - Westerhausen, M
AU  - Westerhausen M
FAU - Hossfeld, D K
AU  - Hossfeld DK
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bone Marrow Cells/metabolism/pathology
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 22/genetics
MH  - Chromosomes, Human, Pair 9/genetics
MH  - Fusion Proteins, bcr-abl/genetics
MH  - Genetic Variation/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - *Philadelphia Chromosome
MH  - Y Chromosome/genetics
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - S0165460899000503 [pii]
AID - 10.1016/s0165-4608(99)00050-3 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Oct 15;114(2):150-3. doi: 
      10.1016/s0165-4608(99)00050-3.