PMID- 10549823
OWN - NLM
STAT- MEDLINE
DCOM- 20000104
LR  - 20211216
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 10
IP  - 14
DP  - 1999 Sep 29
TI  - Tolerance to lipopolysaccharide is related to the nitric oxide pathway.
PG  - 3061-5
AB  - Repeated administration of lipopolysaccharide (LPS) induces a refractory state to 
      its usual pyrogenic effects which is called endotoxin tolerance. We tested the 
      hypothesis that nitric oxide (NO) participates in the endotoxin tolerance. Single 
      injection of LPS resulted in an elevation in body temperature (Tb), whereas a 
      significant reduction of the thermoregulatory response to LPS was observed to 
      repeated administration of LPS (administered at 48 h intervals). 
      Intracerebroventricular (i.c.v.) injection of L-NAME (a non-selective NO 
      inhibitor of nitric oxide synthesis) markedly enhanced the febrile response to 
      LPS in tolerant rats. The data suggest that NO pathway in the central nervous 
      system plays a role in endotoxin tolerance.
FAU - Almeida, M C
AU  - Almeida MC
AD  - Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Brasil.
FAU - Trevisan, F N
AU  - Trevisan FN
FAU - Barros, R C
AU  - Barros RC
FAU - Carnio, E C
AU  - Carnio EC
FAU - Branco, L G
AU  - Branco LG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Bacterial Toxins)
RN  - 0 (Enterotoxins)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (Lipopolysaccharides)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - D9K3SN2LNY (heat-labile enterotoxin, E coli)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type I)
RN  - EC 1.14.13.39 (Nos1 protein, rat)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Bacterial Toxins/*pharmacology
MH  - Body Temperature/drug effects
MH  - Drug Tolerance
MH  - Enterotoxins/*pharmacology
MH  - Enzyme Inhibitors/pharmacology
MH  - Escherichia coli/*metabolism
MH  - *Escherichia coli Proteins
MH  - Fever/chemically induced/physiopathology
MH  - Lipopolysaccharides/*pharmacology
MH  - Male
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Nitric Oxide/*physiology
MH  - Nitric Oxide Synthase/antagonists & inhibitors
MH  - Nitric Oxide Synthase Type I
MH  - Rats
MH  - Rats, Wistar
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - 10.1097/00001756-199909290-00034 [doi]
PST - ppublish
SO  - Neuroreport. 1999 Sep 29;10(14):3061-5. doi: 10.1097/00001756-199909290-00034.