PMID- 10551325
OWN - NLM
STAT- MEDLINE
DCOM- 19991123
LR  - 20240314
IS  - 0910-5050 (Print)
IS  - 1876-4673 (Electronic)
IS  - 0910-5050 (Linking)
VI  - 90
IP  - 9
DP  - 1999 Sep
TI  - Clonal emergence in uremic parathyroid hyperplasia is not related to MEN1 gene 
      abnormality.
PG  - 965-9
AB  - It is difficult to differentiate between parathyroid neoplasia and hyperplasia. 
      In an attempt to elucidate the clonality of uremic parathyroid hyperplasia and 
      the molecular genetic abnormalities accounting for clonal emergence, we analyzed 
      20 cases of uremic parathyroid hyperplasia. Clonalities were determined using the 
      X-chromosome-linked human androgen receptor (HUMARA) gene and the 
      phosphoglycerate kinase (PGK) gene, and multiple endocrine neoplasia type 1 
      (MEN1) gene abnormality was analyzed by studying loss of heterozygosity (LOH) in 
      11q13 and somatic mutations in the MEN1 gene. As a positive control, a case of 
      MEN1 with Zollinger-Ellison syndrome was analyzed simultaneously. Our analysis 
      revealed that a majority (75%) of the uremic parathyroid hyperplasia tissues, 
      including an autograft with recurrent hyperparathyroidism, was of monoclonal 
      origin. Clonality did not correlate with serum carboxyl-terminal parathyroid 
      hormone (C-PTH) level, calcium level, hemodialytic duration, gland weight or 
      pathological features. Neither LOH in 11q13 nor somatic mutation in the MEN1 gene 
      was detected. For the MEN1 case, a germline mutation (W198X) was detected in exon 
      3. We concluded that a majority of the uremic parathyroid hyperplasia cases was 
      in fact monoclonal neoplasia. MEN1 gene abnormality played a minor role, if any, 
      in the clonal emergence in uremic parathyroid hyperplasia.
FAU - Shan, L
AU  - Shan L
AD  - Department of Pathology, Wakayama Medical College. shan@wakayama-med.ac.jp
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Murakami, M
AU  - Murakami M
FAU - Nakamura, M
AU  - Nakamura M
FAU - Naito, A
AU  - Naito A
FAU - Kawahara, K
AU  - Kawahara K
FAU - Utsunomiya, H
AU  - Utsunomiya H
FAU - Mori, I
AU  - Mori I
FAU - Kakudo, K
AU  - Kakudo K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Cancer Res
JT  - Japanese journal of cancer research : Gann
JID - 8509412
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Clone Cells
MH  - Humans
MH  - Hyperplasia/genetics
MH  - Mutation
MH  - Neoplasm Proteins/*genetics
MH  - Parathyroid Glands/metabolism/*pathology
MH  - *Proto-Oncogene Proteins
MH  - Uremia/*genetics
PMC - PMC5926166
EDAT- 1999/11/07 00:00
MHDA- 1999/11/07 00:01
PMCR- 1999/09/01
CRDT- 1999/11/07 00:00
PHST- 1999/11/07 00:00 [pubmed]
PHST- 1999/11/07 00:01 [medline]
PHST- 1999/11/07 00:00 [entrez]
PHST- 1999/09/01 00:00 [pmc-release]
AID - S0910505000800381 [pii]
AID - CAE965 [pii]
AID - 10.1111/j.1349-7006.1999.tb00842.x [doi]
PST - ppublish
SO  - Jpn J Cancer Res. 1999 Sep;90(9):965-9. doi: 10.1111/j.1349-7006.1999.tb00842.x.