PMID- 10552294
OWN - NLM
STAT- MEDLINE
DCOM- 20000111
LR  - 20220408
IS  - 1435-2443 (Print)
IS  - 1435-2443 (Linking)
VI  - 384
IP  - 5
DP  - 1999 Oct
TI  - Tumor size and lymph-node status in pancreatic carcinoma - is there a correlation 
      to the preoperative immune function?
PG  - 473-8
AB  - BACKGROUND AND AIMS: It has not been clarified whether there is a correlation 
      between the tumor size and the preoperative immune function in pancreatic 
      carcinoma. PATIENTS/METHODS: In a prospective trial, the influence of tumor size 
      and lymph-node status on different immune system factors [interleukins (IL)-6 and 
      -10, tumor necrosis factor (TNF)-alpha, CD3-, CD4-, and CD8-lymphocytes, and 
      human leukocyte antigen (HLA)-DR-monocytes] was analyzed in 28 patients with 
      pancreatic carcinoma and compared with a control group (n=20). There were 3 
      pancreatic carcinomas of the T1-tumor type, 20 T2- and 5 T3-tumors; 14 patients 
      were in stage N1. RESULTS: In comparison with the control group, tumor patients 
      preoperatively showed a significant increase of leukocytes (P=0.02), monocytes 
      (P=0. 04), and granulocytes (P=0.03). The total count of lymphocytes, the number 
      of CD3-, CD4- and CD8-lymphocytes, and the expression of HLA-DR on monocytes were 
      significantly decreased as a sign of immunosuppression in tumor patients. A 
      multivariate analysis proved that only tumor size (T-stage) but not lymph-node 
      status correlates with the deficiency of immune competence. Progressive tumor 
      size correlated with decreasing expression of HLA-DR on monocytes, CD3- (P=0.04) 
      and CD8- (P=0.02) lymphocytes. In contrast IL-6, IL-10 (P=0. 04) and TNF-alpha 
      (P=0.02) increased with progressive tumor size. CONCLUSION: Regarding the 
      negative prognosis after resection, the preoperative immune status could be an 
      additional help for decision between a resection or a preoperative immune 
      stimulation in pancreatic carcinoma.
FAU - Wenger, F A
AU  - Wenger FA
AD  - Department of General, Visceral, Vascular and Thoracic Surgery, Charite Campus 
      Mitte, Humboldt-University Berlin, Schumannstr. 20/21, D-10098 Berlin, Germany.
FAU - Jacobi, C A
AU  - Jacobi CA
FAU - Zieren, J
AU  - Zieren J
FAU - Docke, W
AU  - Docke W
FAU - Volk, H D
AU  - Volk HD
FAU - Muller, J M
AU  - Muller JM
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Langenbecks Arch Surg
JT  - Langenbeck's archives of surgery
JID - 9808285
RN  - 0 (Cytokines)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Case-Control Studies
MH  - Cytokines/blood
MH  - Female
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Leukocyte Count
MH  - Logistic Models
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Nutrition Disorders/etiology/immunology
MH  - Pancreatic Neoplasms/*immunology/*pathology/surgery
MH  - Prospective Studies
EDAT- 1999/11/07 00:00
MHDA- 1999/11/07 00:01
CRDT- 1999/11/07 00:00
PHST- 1999/11/07 00:00 [pubmed]
PHST- 1999/11/07 00:01 [medline]
PHST- 1999/11/07 00:00 [entrez]
AID - 93840473.423 [pii]
AID - 10.1007/s004230050233 [doi]
PST - ppublish
SO  - Langenbecks Arch Surg. 1999 Oct;384(5):473-8. doi: 10.1007/s004230050233.