PMID- 10553951
OWN - NLM
STAT- MEDLINE
DCOM- 19991206
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 274
IP  - 2
DP  - 1999 Oct 22
TI  - Induction of a physiologically active brain-derived neurotrophic factor in the 
      infant rat brain by peripheral administration of 4-methylcatechol.
PG  - 115-8
AB  - Effects of 4-methylcatechol (4MC), a known potent stimulator of nerve growth 
      factor (NGF) synthesis, on expression of brain-derived neurotrophic factor (BDNF) 
      mRNA and BDNF-like immunoreactivity (BDNF-LI) was investigated in infant rat 
      brains. A single intraperitoneal administration of 4MC caused transient increases 
      in the levels of BDNF mRNA and BDNF-LI in neurons of the cerebral cortex from 1 
      to 3 h and 3 to 12 h, respectively, after the injection. Repetitive injections of 
      4MC to newborn rats (12-h intervals for 10 days) caused a marked and 
      dose-dependent elevation of the level of BDNF mRNA in the whole brain besides 
      elevating the number of cells containing calbindin D-28 and enhancing its 
      immunoreactive intensity in the pyriform cortex and hippocampus. These findings 
      demonstrate that 4MC stimulates de novo synthesis of BDNF in the infant rat 
      brain, resulting in acceleration of the developmental expression of calbindin 
      D-28.
FAU - Fukumitsu, H
AU  - Fukumitsu H
AD  - Laboratory of Molecular Biology, Gifu Pharmaceutical University Mitahora-higashi, 
      Japan.
FAU - Sometani, A
AU  - Sometani A
FAU - Ohmiya, M
AU  - Ohmiya M
FAU - Nitta, A
AU  - Nitta A
FAU - Nomoto, H
AU  - Nomoto H
FAU - Furukawa, Y
AU  - Furukawa Y
FAU - Furukawa, S
AU  - Furukawa S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Calbindins)
RN  - 0 (Catechols)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (RNA, Messenger)
RN  - 0 (S100 Calcium Binding Protein G)
RN  - 12GLI7JGB3 (4-methylcatechol)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Antibodies
MH  - Blotting, Western
MH  - Brain Chemistry/*drug effects/genetics
MH  - Brain-Derived Neurotrophic Factor/analysis/*genetics/immunology
MH  - Calbindins
MH  - Catechols/*pharmacology
MH  - Cerebral Cortex/chemistry
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression Regulation, Developmental/*drug effects
MH  - Hippocampus/chemistry
MH  - In Situ Hybridization
MH  - Male
MH  - Neuroprotective Agents/*pharmacology
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Wistar
MH  - S100 Calcium Binding Protein G/analysis/immunology
EDAT- 1999/12/20 00:00
MHDA- 1999/12/20 00:01
CRDT- 1999/12/20 00:00
PHST- 1999/12/20 00:00 [pubmed]
PHST- 1999/12/20 00:01 [medline]
PHST- 1999/12/20 00:00 [entrez]
AID - S0304-3940(99)00691-6 [pii]
AID - 10.1016/s0304-3940(99)00691-6 [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 Oct 22;274(2):115-8. doi: 10.1016/s0304-3940(99)00691-6.