PMID- 10554832
OWN - NLM
STAT- MEDLINE
DCOM- 19991130
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 105
IP  - 4
DP  - 1999 Jun
TI  - Heparin lowers plasma levels of activated factor VII.
PG  - 1127-9
AB  - Based on heparin's antithrombin and anti-FXa activity and its in vitro inhibition 
      of activated factor VII (FVIIa) activity, we hypothesized that unfractionated 
      heparin (UFH) may decrease plasma levels of FVIIa in humans. Therefore, 10 
      healthy young male volunteers received an intravenous UFH infusion over 24 h. 
      Heparin decreased FVIIa levels by 30% (95% CI 14-47%) at 12 h, which was 
      sustained until 24 h. In contrast, neither the substrate pool (i.e. total factor 
      VII) as measured by FVII antigen nor FVII activity were affected by UFH. These 
      results may improve our understanding of the regulation of FVIIa levels and 
      heparin's mode of action.
FAU - Pernerstorfer, T
AU  - Pernerstorfer T
AD  - Department of Clinical Pharmacology-TARGET, University of Vienna, Austria. 
      thomas.pernerstorfer@univie.ac.at
FAU - Jilma, B
AU  - Jilma B
FAU - Eichler, H G
AU  - Eichler HG
FAU - Aull, S
AU  - Aull S
FAU - Handler, S
AU  - Handler S
FAU - Speiser, W
AU  - Speiser W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Anticoagulants)
RN  - 9001-25-6 (Factor VII)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Adult
MH  - Anticoagulants/*pharmacology
MH  - Factor VII/*metabolism
MH  - Heparin/*pharmacology
MH  - Humans
MH  - Male
MH  - Plasma/chemistry
MH  - Tissue Plasminogen Activator/metabolism
EDAT- 1999/11/11 00:00
MHDA- 1999/11/11 00:01
CRDT- 1999/11/11 00:00
PHST- 1999/11/11 00:00 [pubmed]
PHST- 1999/11/11 00:01 [medline]
PHST- 1999/11/11 00:00 [entrez]
AID - 10.1046/j.1365-2141.1999.01473.x [doi]
PST - ppublish
SO  - Br J Haematol. 1999 Jun;105(4):1127-9. doi: 10.1046/j.1365-2141.1999.01473.x.